1 Ocak 2017 Dergi makalesi Açık Erişim

Aktas, Erdem; Chamberlain, Connie S.; Saether, Erin E.; Duenwald-Kuehl, Sarah E.; Kondratko-Mittnacht, Jaclyn; Stitgen, Michael; Lee, Jae Sung; Clements, Anna E.; Murphy, William L.; Vanderby, Ray

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{
  "@context": "https://schema.org/", 
  "@id": 46743, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Ankara Oncol Res & Training Hosp, Dept Orthoped, Ankara, Turkey", 
      "name": "Aktas, Erdem"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Wisconsin, Dept Orthoped & Rehabil, Madison, WI 53705 USA", 
      "name": "Chamberlain, Connie S."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Wisconsin, Dept Biomed Engn, Madison, WI 53705 USA", 
      "name": "Saether, Erin E."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Wisconsin, Dept Biomed Engn, Madison, WI 53705 USA", 
      "name": "Duenwald-Kuehl, Sarah E."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Wisconsin, Dept Biomed Engn, Madison, WI 53705 USA", 
      "name": "Kondratko-Mittnacht, Jaclyn"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Wisconsin, Dept Biomed Engn, Madison, WI 53705 USA", 
      "name": "Stitgen, Michael"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Wisconsin, Dept Biomed Engn, Madison, WI 53705 USA", 
      "name": "Lee, Jae Sung"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Wisconsin, Dept Orthoped & Rehabil, Madison, WI 53705 USA", 
      "name": "Clements, Anna E."
    }, 
    {
      "@type": "Person", 
      "name": "Murphy, William L."
    }, 
    {
      "@type": "Person", 
      "name": "Vanderby, Ray"
    }
  ], 
  "datePublished": "2017-01-01", 
  "description": "Tendon healing is a complex coordinated series of events resulting in protracted recovery, limited regeneration, and scar formation. Mesenchymal stem cell (MSC) therapy has shown promise as a new technology to enhance soft tissue and bone healing. A challenge with MSC therapy involves the ability to consistently control the inflammatory response and subsequent healing. Previous studies suggest that preconditioning MSCs with inflammatory cytokines, such as IFN-, TNF-, and IL-1 may accelerate cutaneous wound closure. The objective of this study was to therefore elucidate these effects in tendon. That is, the in vivo healing effects of TNF- primed MSCs were studied using a rat Achilles segmental defect model. Rat Achilles tendons were subjected to a unilateral 3mm segmental defect and repaired with either a PLG scaffold alone, MSC-seeded PLG scaffold, or TNF--primed MSC-seeded PLG scaffold. Achilles tendons were analyzed at 2 and 4 weeks post-injury. In vivo, MSCs, regardless of priming, increased IL-10 production and reduced the inflammatory factor, IL-1. Primed MSCs reduced IL-12 production and the number of M1 macrophages, as well as increased the percent of M2 macrophages, and synthesis of the anti-inflammatory factor IL-4. Primed MSC treatment also increased the concentration of type I procollagen in the healing tissue and increased failure stress of the tendon 4 weeks post-injury. Taken together delivery of TNF- primed MSCs via 3D PLG scaffold modulated macrophage polarization and cytokine production to further accentuate the more regenerative MSC-induced healing response. (c) 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:269-280, 2017.", 
  "headline": "Immune modulation with primed mesenchymal stem cells delivered via biodegradable scaffold to repair an Achilles tendon segmental defect", 
  "identifier": 46743, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Immune modulation with primed mesenchymal stem cells delivered via biodegradable scaffold to repair an Achilles tendon segmental defect", 
  "url": "https://aperta.ulakbim.gov.tr/record/46743"
}