1 Ocak 2021 Dergi makalesi Açık Erişim

Karadeniz, Eda; Kelgokmen, Yilmaz; Zora, Metin

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  <dc:creator>Karadeniz, Eda</dc:creator>
  <dc:creator>Kelgokmen, Yilmaz</dc:creator>
  <dc:creator>Zora, Metin</dc:creator>
  <dc:date>2021-01-01</dc:date>
  <dc:description>An efficient and general method for the synthesis of spiro-1,4-oxazepines and 3,3-dimethyl-1,4-oxazepines is reported. When treated with ZnI2 and AgSbF6 in refluxing DCE, cyclohexane-embedded N-propargylic beta-enaminones underwent 7-exo-dig cyclization to afford spiro-1,4-oxazepines, specifically 12-methylene-11-oxa-7-azaspiro[5.6]dodeca-7,9-dienes, in good to high yields. Accordingly, N-(1,1-dimethyl)propargylic beta-enaminones produced 3,3-dimethyl-1,4-oxazepines. Cyclization was found to be general for a diverse range of N-propargylic beta-enaminones with high efficiency and broad functional group tolerance. This operationally easy method might provide quick access to a library of functionalized spiro and gem-dimethyl-substituted 1,4-oxazepine derivatives of pharmacological interest.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/4525</dc:identifier>
  <dc:identifier>oai:zenodo.org:4525</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>JOURNAL OF HETEROCYCLIC CHEMISTRY 58(2) 466-477</dc:source>
  <dc:title>A new approach for the synthesis of spiro and gem-dimethyl-substituted 1,4-oxazepines from N-propargylic beta-enaminones</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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