1 Ocak 2021 Dergi makalesi Açık Erişim

Karadeniz, Eda; Kelgokmen, Yilmaz; Zora, Metin

JSON

{
  "conceptrecid": "4524", 
  "created": "2021-03-15T06:00:02.652292+00:00", 
  "doi": "10.1002/jhet.4183", 
  "files": [
    {
      "bucket": "9f42ca62-0983-4c21-a05a-22c0ee9d4b7a", 
      "checksum": "md5:57bccc79a4ab305a07bc7471f5d86106", 
      "key": "bib-dd64f969-9114-4111-9855-d1cccd598d9b.txt", 
      "links": {
        "self": "https://aperta.ulakbim.gov.tr/api/files/9f42ca62-0983-4c21-a05a-22c0ee9d4b7a/bib-dd64f969-9114-4111-9855-d1cccd598d9b.txt"
      }, 
      "size": 220, 
      "type": "txt"
    }
  ], 
  "id": 4525, 
  "links": {
    "badge": "https://aperta.ulakbim.gov.tr/badge/doi/10.1002/jhet.4183.svg", 
    "bucket": "https://aperta.ulakbim.gov.tr/api/files/9f42ca62-0983-4c21-a05a-22c0ee9d4b7a", 
    "doi": "https://doi.org/10.1002/jhet.4183", 
    "html": "https://aperta.ulakbim.gov.tr/record/4525", 
    "latest": "https://aperta.ulakbim.gov.tr/api/records/4525", 
    "latest_html": "https://aperta.ulakbim.gov.tr/record/4525"
  }, 
  "metadata": {
    "access_right": "open", 
    "access_right_category": "success", 
    "communities": [
      {
        "id": "tubitak-destekli-proje-yayinlari"
      }
    ], 
    "creators": [
      {
        "affiliation": "Middle East Tech Univ, Dept Chem, TR-06800 Ankara, Turkey", 
        "name": "Karadeniz, Eda"
      }, 
      {
        "affiliation": "Middle East Tech Univ, Dept Chem, TR-06800 Ankara, Turkey", 
        "name": "Kelgokmen, Yilmaz"
      }, 
      {
        "affiliation": "Middle East Tech Univ, Dept Chem, TR-06800 Ankara, Turkey", 
        "name": "Zora, Metin"
      }
    ], 
    "description": "An efficient and general method for the synthesis of spiro-1,4-oxazepines and 3,3-dimethyl-1,4-oxazepines is reported. When treated with ZnI2 and AgSbF6 in refluxing DCE, cyclohexane-embedded N-propargylic beta-enaminones underwent 7-exo-dig cyclization to afford spiro-1,4-oxazepines, specifically 12-methylene-11-oxa-7-azaspiro[5.6]dodeca-7,9-dienes, in good to high yields. Accordingly, N-(1,1-dimethyl)propargylic beta-enaminones produced 3,3-dimethyl-1,4-oxazepines. Cyclization was found to be general for a diverse range of N-propargylic beta-enaminones with high efficiency and broad functional group tolerance. This operationally easy method might provide quick access to a library of functionalized spiro and gem-dimethyl-substituted 1,4-oxazepine derivatives of pharmacological interest.", 
    "doi": "10.1002/jhet.4183", 
    "has_grant": false, 
    "journal": {
      "issue": "2", 
      "pages": "466-477", 
      "title": "JOURNAL OF HETEROCYCLIC CHEMISTRY", 
      "volume": "58"
    }, 
    "license": {
      "id": "cc-by"
    }, 
    "publication_date": "2021-01-01", 
    "relations": {
      "version": [
        {
          "count": 1, 
          "index": 0, 
          "is_last": true, 
          "last_child": {
            "pid_type": "recid", 
            "pid_value": "4525"
          }, 
          "parent": {
            "pid_type": "recid", 
            "pid_value": "4524"
          }
        }
      ]
    }, 
    "resource_type": {
      "subtype": "article", 
      "title": "Dergi makalesi", 
      "type": "publication"
    }, 
    "title": "A new approach for the synthesis of spiro and gem-dimethyl-substituted 1,4-oxazepines from N-propargylic beta-enaminones"
  }, 
  "owners": [
    1
  ], 
  "revision": 1, 
  "stats": {
    "downloads": 3.0, 
    "unique_downloads": 3.0, 
    "unique_views": 31.0, 
    "version_downloads": 3.0, 
    "version_unique_downloads": 3.0, 
    "version_unique_views": 31.0, 
    "version_views": 35.0, 
    "version_volume": 660.0, 
    "views": 35.0, 
    "volume": 660.0
  }, 
  "updated": "2021-03-15T06:00:02.695239+00:00"
}