Dergi makalesi Açık Erişim
Hu, Xiaozhou; Baytak, Esra; Li, Jinnan; Akman, Burcu; Okay, Kaan; Hu, Genfu; Scuto, Anna; Zhang, Wenyan; Kucuk, Can
<?xml version='1.0' encoding='UTF-8'?> <record xmlns="http://www.loc.gov/MARC21/slim"> <leader>00000nam##2200000uu#4500</leader> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Baytak, Esra</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Li, Jinnan</subfield> <subfield code="u">Sichuan Univ, West China Hosp, Dept Pathol, Chengdu, Guangxi, Peoples R China</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Akman, Burcu</subfield> <subfield code="u">Dokuz Eylul Univ, Izmir Int Biomed & Genome Inst iBG Izmir, Izmir, Turkey</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Okay, Kaan</subfield> <subfield code="u">Dokuz Eylul Univ, Izmir Int Biomed & Genome Inst iBG Izmir, Izmir, Turkey</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Hu, Genfu</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Scuto, Anna</subfield> <subfield code="u">City Hope Med Ctr, Dept Pathol, Duarte, CA USA</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Zhang, Wenyan</subfield> <subfield code="u">Sichuan Univ, West China Hosp, Dept Pathol, Chengdu, Guangxi, Peoples R China</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Kucuk, Can</subfield> </datafield> <datafield tag="909" ind1="C" ind2="4"> <subfield code="c">30-38</subfield> <subfield code="p">LEUKEMIA RESEARCH</subfield> <subfield code="v">54</subfield> </datafield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="540" ind1=" " ind2=" "> <subfield code="a">Creative Commons Attribution</subfield> <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield> </datafield> <datafield tag="024" ind1=" " ind2=" "> <subfield code="a">10.1016/j.leukres.2017.01.001</subfield> <subfield code="2">doi</subfield> </datafield> <datafield tag="245" ind1=" " ind2=" "> <subfield code="a">The relationship of REL proto-oncogene to pathobiology and chemoresistance in follicular and transformed follicular lymphoma</subfield> </datafield> <datafield tag="100" ind1=" " ind2=" "> <subfield code="a">Hu, Xiaozhou</subfield> <subfield code="u">Dokuz Eylul Univ, Izmir Int Biomed & Genome Inst iBG Izmir, Izmir, Turkey</subfield> </datafield> <datafield tag="909" ind1="C" ind2="O"> <subfield code="o">oai:zenodo.org:43897</subfield> <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="650" ind1="1" ind2="7"> <subfield code="2">opendefinition.org</subfield> <subfield code="a">cc-by</subfield> </datafield> <datafield tag="260" ind1=" " ind2=" "> <subfield code="c">2017-01-01</subfield> </datafield> <datafield tag="856" ind1="4" ind2=" "> <subfield code="u">https://aperta.ulakbim.gov.trrecord/43897/files/bib-cdc083f8-f00f-4092-aa93-e52a98c9ee23.txt</subfield> <subfield code="z">md5:fac5332ebe39e791580056a585a754c6</subfield> <subfield code="s">259</subfield> </datafield> <datafield tag="542" ind1=" " ind2=" "> <subfield code="l">open</subfield> </datafield> <controlfield tag="005">20210315211411.0</controlfield> <controlfield tag="001">43897</controlfield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">publication</subfield> <subfield code="b">article</subfield> </datafield> <datafield tag="520" ind1=" " ind2=" "> <subfield code="a">Follicular lymphoma (FL) is a common type of indolent lymphoma that occasionally transforms to more aggressive B-cell lymphomas. These transformed follicular lymphomas (tFL) are often associated with chemoresistance whose mechanisms are currently unknown. REL, a proto-oncogene located on frequently amplified 2p16.1-p15 locus, promotes tumorigenesis in many cancer types through deregulation of the NF-KB pathway; however, its role in FL pathobiology or chemoresistance has not been addressed. Here, we evaluated REL gene copy number by q-PCR on FFPE FL tumor samples, and observed REL amplification in 30.4% of FL cases that was associated with weak elevation of transcript levels. PCR-Sanger analysis did not show any somatic mutation in FL tumors. In support of a marginal oncogenic role, a REL-transduced FL cell line was positively selected under limiting serum conditions. Interestingly, reanalysis of previously reported gene expression profiles revealed significant enrichment of DNA damage-induced repair and cell cycle arrest pathways in tFL tumors with high REL expression compared to those with low REL expression consistent with the critical role of c-REL in genotoxicity-induced NF-KB signaling, which was reported to lead to drug resistance. In addition to DNA damage repair genes such as ATM and BRCA1, anti-apoptotic BCL2 was significantly elevated in REL-high FL and tFL tumors. Altogether these data suggest that other genes located in amplified 2p16.1-p15 locus may have more oncogenic role in FL etiology; however, high REL expression may be useful as a predictive biomarker of response to immunochemotherapy, and inhibition of c-REL may potentially sensitize resistant FL or tFL cells to chemotherapy. (C) 2017 Elsevier Ltd. All rights reserved.</subfield> </datafield> </record>
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