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A resampling-based meta-analysis for detection of differential gene expression in breast cancer

Gur-Dedeoglu, Bala; Konu, Ozlen; Kir, Serkan; Ozturk, Ahmet Rasit; Bozkurt, Betul; Ergul, Gulusan; Yulug, Isik G.


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{
  "DOI": "10.1186/1471-2407-8-396", 
  "abstract": "Background: Accuracy in the diagnosis of breast cancer and classification of cancer subtypes has improved over the years with the development of well-established immunohistopathological criteria. More recently, diagnostic gene-sets at the mRNA expression level have been tested as better predictors of disease state. However, breast cancer is heterogeneous in nature; thus extraction of differentially expressed gene-sets that stably distinguish normal tissue from various pathologies poses challenges. Meta-analysis of high-throughput expression data using a collection of statistical methodologies leads to the identification of robust tumor gene expression signatures.", 
  "author": [
    {
      "family": "Gur-Dedeoglu", 
      "given": " Bala"
    }, 
    {
      "family": "Konu", 
      "given": " Ozlen"
    }, 
    {
      "family": "Kir", 
      "given": " Serkan"
    }, 
    {
      "family": "Ozturk", 
      "given": " Ahmet Rasit"
    }, 
    {
      "family": "Bozkurt", 
      "given": " Betul"
    }, 
    {
      "family": "Ergul", 
      "given": " Gulusan"
    }, 
    {
      "family": "Yulug", 
      "given": " Isik G."
    }
  ], 
  "container_title": "BMC CANCER", 
  "id": "41529", 
  "issued": {
    "date-parts": [
      [
        2008, 
        1, 
        1
      ]
    ]
  }, 
  "title": "A resampling-based meta-analysis for detection of differential gene expression in breast cancer", 
  "type": "article-journal", 
  "volume": "8"
}
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