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Synthesis of beta-chloro-alpha-aminophosphonate derivatives via the regioselective ring opening of unactivated aziridine-2-phosphonates

Polat-Cakir, Sidika; Beksultanova, Nurzhan; Dogan, Ozdemir


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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/33007</identifier>
  <creators>
    <creator>
      <creatorName>Polat-Cakir, Sidika</creatorName>
      <givenName>Sidika</givenName>
      <familyName>Polat-Cakir</familyName>
      <affiliation>Canakkale Onsekiz Mart Univ, Dept Chem Engn, Canakkale, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Beksultanova, Nurzhan</creatorName>
      <givenName>Nurzhan</givenName>
      <familyName>Beksultanova</familyName>
      <affiliation>Middle East Tech Univ, Dept Chem, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Dogan, Ozdemir</creatorName>
      <givenName>Ozdemir</givenName>
      <familyName>Dogan</familyName>
      <affiliation>Middle East Tech Univ, Dept Chem, Ankara, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Synthesis Of Beta-Chloro-Alpha-Aminophosphonate Derivatives Via The Regioselective Ring Opening Of Unactivated Aziridine-2-Phosphonates</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2018</publicationYear>
  <dates>
    <date dateType="Issued">2018-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/33007</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1080/10426507.2018.1513521</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">A series of unactivated racemic and chiral aziridine-2-phosphonates were synthesized by modified Gabriel-Cromwell reaction. Ring opening reaction of the synthesized phosphonates by gaseous HCl provided access to a wide range of biologically interesting novel beta-chloro-alpha-aminophosphonates. All reactions toward each of the above-mentioned products can be conducted regioselectively in high yields.</description>
  </descriptions>
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