1 Ocak 2010 Dergi makalesi Açık Erişim

Gungormusler, Mine; Gonen, Cagdas; Ozdemir, Guven; Azbar, Nuri

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/26727</identifier>
  <creators>
    <creator>
      <creatorName>Gungormusler, Mine</creatorName>
      <givenName>Mine</givenName>
      <familyName>Gungormusler</familyName>
      <affiliation>Ege Univ, Dept Bioengn, Fac Engn, TR-35100 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Gonen, Cagdas</creatorName>
      <givenName>Cagdas</givenName>
      <familyName>Gonen</familyName>
      <affiliation>Ege Univ, Dept Bioengn, Fac Engn, TR-35100 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozdemir, Guven</creatorName>
      <givenName>Guven</givenName>
      <familyName>Ozdemir</familyName>
      <affiliation>Ege Univ, Dept Biol, Fac Sci, TR-35100 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Azbar, Nuri</creatorName>
      <givenName>Nuri</givenName>
      <familyName>Azbar</familyName>
      <affiliation>Ege Univ, Dept Bioengn, Fac Engn, TR-35100 Izmir, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Fermentation Medium Optimization For 1,3-Propanediol Production Using Taguchi And Box-Behnken Experimental Designs</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2010</publicationYear>
  <dates>
    <date dateType="Issued">2010-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/26727</alternateIdentifier>
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    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsVersionOf">10.81043/aperta.26726</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.81043/aperta.26727</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Klebsiella species are excellent 1,3-propanediol (1,3 PDO) producers. Klebsiella pneumoniae is a well-studied microorganism and, therefore, its metabolic pathway is known. Accordingly, a number of by-products are simultaneously produced together with 1,3 PDO. Optimization of medium composition significantly decreased these by-products' concentrations. Optimization of culture media concentrations on 1,3 PDO production by K. pneumoniae was studied using statistical experimental designs and analysis, namely, Taguchi Orthogonal Array (TOA) and Box-Behnken design (BBD). The optimal composition of the fermentation medium for maximum 1,3 PDO yield, with a LIS (2 boolean AND 1 x 3 boolean AND 7) design using TOA, and after that, a three-level three-factor BBD, was obtained. The most significant chemicals were found to be glycerol (p&amp;lt;0.0001) and K2HPO4 (p&amp;lt;0.05). MgSO4 center dot 7H(2)0, which is the third significant factor obtained from TOA, was not found to be significant (p&amp;gt;0.05) from BBD. A maximum 1,3 PDO concentration of 23.6 g/L was obtained which is higher compared to that foreseen by the statistical model (9.3 g/L).</description>
  </descriptions>
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