1 Ocak 2023 Dergi makalesi Açık Erişim

Peiro, Jose L.; Duru, Soner; Fernandez-Tome, Blanca; Peiro, Lucas; Encinas, Jose L.; Sanchez-Margallo, Francisco M.; Oria, Marc

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/265704</identifier>
  <creators>
    <creator>
      <creatorName>Peiro, Jose L.</creatorName>
      <givenName>Jose L.</givenName>
      <familyName>Peiro</familyName>
    </creator>
    <creator>
      <creatorName>Duru, Soner</creatorName>
      <givenName>Soner</givenName>
      <familyName>Duru</familyName>
      <affiliation>Cincinnati Childrens Hosp Med Ctr CCHMC, Ctr Fetal &amp; Placental Res, Div Pediat Gen &amp; Thorac Surg, Cincinnati, OH USA</affiliation>
    </creator>
    <creator>
      <creatorName>Fernandez-Tome, Blanca</creatorName>
      <givenName>Blanca</givenName>
      <familyName>Fernandez-Tome</familyName>
      <affiliation>Jesus Uson Minimally Invas Surg Ctr JUMISC, Caceres, Spain</affiliation>
    </creator>
    <creator>
      <creatorName>Peiro, Lucas</creatorName>
      <givenName>Lucas</givenName>
      <familyName>Peiro</familyName>
    </creator>
    <creator>
      <creatorName>Encinas, Jose L.</creatorName>
      <givenName>Jose L.</givenName>
      <familyName>Encinas</familyName>
      <affiliation>Hosp La Paz, Dept Pediat Surg, Madrid, Spain</affiliation>
    </creator>
    <creator>
      <creatorName>Sanchez-Margallo, Francisco M.</creatorName>
      <givenName>Francisco M.</givenName>
      <familyName>Sanchez-Margallo</familyName>
      <affiliation>Jesus Uson Minimally Invas Surg Ctr JUMISC, Caceres, Spain</affiliation>
    </creator>
    <creator>
      <creatorName>Oria, Marc</creatorName>
      <givenName>Marc</givenName>
      <familyName>Oria</familyName>
    </creator>
  </creators>
  <titles>
    <title>Fetal Endoscopic Third Ventriculostomy Is Technically Feasible In Prenatally Induced Hydrocephalus Ovine Model</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2023</publicationYear>
  <dates>
    <date dateType="Issued">2023-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/265704</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1227/neu.0000000000002361</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;BACKGROUND:Congenital obstructive hydrocephalus generates progressive irreversible fetal brain damage by ventricular enlargement and incremental brain tissue compression that leads to maldevelopment and poor clinical outcomes. Intrauterine treatments such as ventriculo-amniotic shunting have been unsuccessfully tried in the eighties.OBJECTIVE:To assess if prenatal endoscopic third ventriculostomy (ETV) is feasible in a large animal model and optimize this technique for ventricular decompression and potential arrest of fetal brain damage in fetal lambs.METHODS:We generated hydrocephalus in 50 fetal lambs by injecting a polymeric agent into the cisterna magna at midgestation (E85). Subsequently, 3 weeks later (E105), fetal ETV was performed using a small rigid fetoscope. The endoscopy entry point was located anterior to the coronal suture, 7 mm from the midline.RESULTS:We obtained clear visualization of the enlarged lateral ventricles by endoscopy in the hydrocephalic fetal lambs. The floor of the third ventricle was bluntly perforated and passed with the scope for a successful ETV. Total success was achieved in 32/50 cases (64%). Causes of failure were blurred vision or third ventricle obliteration by BioGlue in 10/50 (20%) cases, anatomic misdirection of the endoscope in 5 (10%) cases, 2 cases of very narrow foramen of Monro, and 1 case of choroid plexus bleeding. If we exclude the cases artificially blocked by the polymer, we had a successful performance of prenatal-ETV in 80% (32/40) of hydrocephalic fetuses.CONCLUSION:Despite the inherent difficulties arising from ovine brain anatomy, this study shows that innovative fetal ETV is technically feasible in hydrocephalic fetal lambs.&lt;/p&gt;</description>
  </descriptions>
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