1 Ocak 2022 Dergi makalesi Açık Erişim

Oktay, Ayse Nur; Polli, James E.

JSON

{
  "conceptrecid": "261646", 
  "created": "2023-07-29T15:25:27.340203+00:00", 
  "doi": "10.1016/j.ijpharm.2022.122015", 
  "files": [
    {
      "bucket": "222a8f18-6092-40d7-9554-2cf547309af2", 
      "checksum": "md5:7feb4dbd53ff3f085532acff82f825ab", 
      "key": "bib-f016b019-8981-43ff-b450-f8370adafde5.txt", 
      "links": {
        "self": "https://aperta.ulakbim.gov.tr/api/files/222a8f18-6092-40d7-9554-2cf547309af2/bib-f016b019-8981-43ff-b450-f8370adafde5.txt"
      }, 
      "size": 233, 
      "type": "txt"
    }
  ], 
  "id": 261647, 
  "links": {
    "badge": "https://aperta.ulakbim.gov.tr/badge/doi/10.1016/j.ijpharm.2022.122015.svg", 
    "bucket": "https://aperta.ulakbim.gov.tr/api/files/222a8f18-6092-40d7-9554-2cf547309af2", 
    "doi": "https://doi.org/10.1016/j.ijpharm.2022.122015", 
    "html": "https://aperta.ulakbim.gov.tr/record/261647", 
    "latest": "https://aperta.ulakbim.gov.tr/api/records/261647", 
    "latest_html": "https://aperta.ulakbim.gov.tr/record/261647"
  }, 
  "metadata": {
    "access_right": "open", 
    "access_right_category": "success", 
    "communities": [
      {
        "id": "tubitak-destekli-proje-yayinlari"
      }
    ], 
    "creators": [
      {
        "name": "Oktay, Ayse Nur"
      }, 
      {
        "affiliation": "Univ Maryland, Dept Pharmaceut Sci, 20 Penn St, Baltimore, MD 21201 USA", 
        "name": "Polli, James E."
      }
    ], 
    "description": "Etravirine is an antiviral whose oral absorption is limited by low solubility/dissolution. The objective was to predict and compare etravirine's surfactant-mediated dissolution into polyoxyethylene-10 lauryl ether (POE) and FeSSIF-V2, including the contribution of slow micelle diffusivity. Dynamic light scattering (DLS) was used to measure the size and diffusivity values of drug-loaded micelles. In vitro intrinsic dissolution into surfactant media were predicted using a model for surfactant-mediated dissolution. Compared to maleic buffer, POE and FeSSIF-V2 increased etravirine solubility 232-fold and 8.97-fold, respectively. From DLS, micelle diffusivity of drug-loaded POE micelle and FeSSIF-V2 mixed-micelle was 5.15x10(-7) cm(2)/s and 5.76x10(-8) cm(2)/s, respectively. Observed and predicted dissolution enhancement into POE were 50.7 and 31.3, and 1.26 and 1.24 into FeSSIF-V2, respectively. Hence, there was high dissolution enhancement into POE, although the observed enhancement was only 21.9% of the observed solubility enhancement, reflecting the attenuating impact of the large and slowly diffusing drug-loaded POE micelles. Meanwhile, there was minimal dissolution enhancement into FeSSIF-V2, and the observed enhancement was only 14.0% of the observed solubility enhancement, reflecting the even slower diffusing drug-loaded FeSSIF-V2 mixed-micelles compared to drug-loaded POE micelles. Results are considered in light of designing a single pharmaceutical surfactant system for dissolution that mimics a FeSSIF-V2 system.", 
    "doi": "10.1016/j.ijpharm.2022.122015", 
    "has_grant": false, 
    "journal": {
      "title": "INTERNATIONAL JOURNAL OF PHARMACEUTICS", 
      "volume": "624"
    }, 
    "license": {
      "id": "cc-by"
    }, 
    "publication_date": "2022-01-01", 
    "relations": {
      "version": [
        {
          "count": 1, 
          "index": 0, 
          "is_last": true, 
          "last_child": {
            "pid_type": "recid", 
            "pid_value": "261647"
          }, 
          "parent": {
            "pid_type": "recid", 
            "pid_value": "261646"
          }
        }
      ]
    }, 
    "resource_type": {
      "subtype": "article", 
      "title": "Dergi makalesi", 
      "type": "publication"
    }, 
    "science_branches": [
      "Di\u011fer"
    ], 
    "title": "Comparison of a single pharmaceutical surfactant versus intestinal biorelevant media for etravirine dissolution: Role and impact of micelle diffusivity"
  }, 
  "owners": [
    1
  ], 
  "revision": 1, 
  "stats": {
    "downloads": 9.0, 
    "unique_downloads": 9.0, 
    "unique_views": 38.0, 
    "version_downloads": 9.0, 
    "version_unique_downloads": 9.0, 
    "version_unique_views": 33.0, 
    "version_views": 37.0, 
    "version_volume": 2097.0, 
    "views": 42.0, 
    "volume": 2097.0
  }, 
  "updated": "2023-07-29T15:25:27.397261+00:00"
}