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Inter-vendor performance of deep learning in segmenting acute ischemic lesions on diffusion-weighted imaging: a multicenter study

Alis, Deniz; Yergin, Mert; Alis, Ceren; Topel, Cagdas; Asmakutlu, Ozan; Bagcilar, Omer; Senli, Yeseren Deniz; Ustundag, Ahmet; Salt, Vefa; Dogan, Sebahat Nacar; Velioglu, Murat; Selcuk, Hakan Hatem; Kara, Batuhan; Oksuz, Ilkay; Kizilkilic, Osman; Karaarslan, Ercan


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      {
        "affiliation": "Acibadem Mehmet Ali Aydinlar Univ, Dept Radiol, Sch Med, Istanbul, Turkey", 
        "name": "Alis, Deniz"
      }, 
      {
        "affiliation": "Bahcesehir Univ, Dept Software Engn & Appl Sci, Istanbul, Turkey", 
        "name": "Yergin, Mert"
      }, 
      {
        "affiliation": "Istanbul Univ Cerrahpasa, Cerrahpasa Med Fac, Neurol Dept, Istanbul, Turkey", 
        "name": "Alis, Ceren"
      }, 
      {
        "affiliation": "Istanbul Mehmet Akif Ersoy Thorac & Cardiovasc Su, Dept Radiol, Halkali Istanbul, Turkey", 
        "name": "Topel, Cagdas"
      }, 
      {
        "affiliation": "Istanbul Mehmet Akif Ersoy Thorac & Cardiovasc Su, Dept Radiol, Halkali Istanbul, Turkey", 
        "name": "Asmakutlu, Ozan"
      }, 
      {
        "affiliation": "Istanbul Silivri State Hosp, Radiol Dept, Istanbul, Turkey", 
        "name": "Bagcilar, Omer"
      }, 
      {
        "affiliation": "Istanbul Univ Cerrahpasa, Cerrahpasa Med Fac, Radiol Dept, Istanbul, Turkey", 
        "name": "Senli, Yeseren Deniz"
      }, 
      {
        "affiliation": "Istanbul Univ Cerrahpasa, Cerrahpasa Med Fac, Radiol Dept, Istanbul, Turkey", 
        "name": "Ustundag, Ahmet"
      }, 
      {
        "affiliation": "Istanbul Univ Cerrahpasa, Cerrahpasa Med Fac, Radiol Dept, Istanbul, Turkey", 
        "name": "Salt, Vefa"
      }, 
      {
        "affiliation": "Istanbul Gaziosmanpasa Training & Res Hosp, Radiol Dept, Istanbul, Turkey", 
        "name": "Dogan, Sebahat Nacar"
      }, 
      {
        "affiliation": "Istanbul Fatih Sultan Mehmet Training & Res Hosp, Radiol Dept, Istanbul, Turkey", 
        "name": "Velioglu, Murat"
      }, 
      {
        "affiliation": "Istanbul Bakirkoy Sadi Konuk Training & Res Hosp, Radiol Dept, Istanbul, Turkey", 
        "name": "Selcuk, Hakan Hatem"
      }, 
      {
        "affiliation": "Istanbul Bakirkoy Sadi Konuk Training & Res Hosp, Radiol Dept, Istanbul, Turkey", 
        "name": "Kara, Batuhan"
      }, 
      {
        "affiliation": "Istanbul Tech Univ, Dept Software Engn & Appl Sci, Istanbul, Turkey", 
        "name": "Oksuz, Ilkay"
      }, 
      {
        "affiliation": "Istanbul Univ Cerrahpasa, Cerrahpasa Med Fac, Radiol Dept, Istanbul, Turkey", 
        "name": "Kizilkilic, Osman"
      }, 
      {
        "affiliation": "Acibadem Mehmet Ali Aydinlar Univ, Dept Radiol, Sch Med, Istanbul, Turkey", 
        "name": "Karaarslan, Ercan"
      }
    ], 
    "description": "There is little evidence on the applicability of deep learning (DL) in the segmentation of acute ischemic lesions on diffusion-weighted imaging (DWI) between magnetic resonance imaging (MRI) scanners of different manufacturers. We retrospectively included DWI data of patients with acute ischemic lesions from six centers. Dataset A (n=2986) and B (n=3951) included data from Siemens and GE MRI scanners, respectively. The datasets were split into the training (80%), validation (10%), and internal test (10%) sets, and six neuroradiologists created ground-truth masks. Models A and B were the proposed neural networks trained on datasets A and B. The models subsequently fine-tuned across the datasets using their validation data. Another radiologist performed the segmentation on the test sets for comparisons. The median Dice scores of models A and B were 0.858 and 0.857 for the internal tests, which were non-inferior to the radiologist's performance, but demonstrated lower performance than the radiologist on the external tests. Fine-tuned models A and B achieved median Dice scores of 0.832 and 0.846, which were non-inferior to the radiologist's performance on the external tests. The present work shows that the inter-vendor operability of deep learning for the segmentation of ischemic lesions on DWI might be enhanced via transfer learning; thereby, their clinical applicability and generalizability could be improved.", 
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      "issue": "1", 
      "title": "SCIENTIFIC REPORTS", 
      "volume": "11"
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    "publication_date": "2021-01-01", 
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    "title": "Inter-vendor performance of deep learning in segmenting acute ischemic lesions on diffusion-weighted imaging: a multicenter study"
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