1 Ocak 2021 Dergi makalesi Açık Erişim

Cagatay, Elcin; Akyildiz, Volkan; Ergun, Yavuz; Kayali, Hulya Ayar

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  "@id": 234308, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "name": "Cagatay, Elcin"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ataturk Univ, Fac Sci, Dept Chem, Erzurum, Turkey", 
      "name": "Akyildiz, Volkan"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Dokuz Eylul Univ, Fac Sci, Dept Chem, TR-35160 Izmir, Turkey", 
      "name": "Ergun, Yavuz"
    }, 
    {
      "@type": "Person", 
      "name": "Kayali, Hulya Ayar"
    }
  ], 
  "datePublished": "2021-01-01", 
  "description": "A series of novel murrayaquinone a derivatives were synthesized and their anti-cancer activity were evaluated on healthy colon cell lines (CCD-18Co), primary (Caco-2) and metastatic (DLD-1) colon cancer cell lines. The results showed that the cytotoxicity of murrayaquinone molecules is significantly high even in micromolar levels. The DNA binding, cell cycle arrest and metabolic activity studies of these molecules were also carried out and the results showed that these molecules induce apoptosis. In conclusion, the data support further studies on murrayaquinone derivatives toward selection of a candidate for cancer treatment.", 
  "headline": "Synthesis of Murrayaquinone-A Derivatives and Investigation of Potential Anticancer Properties", 
  "identifier": 234308, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Synthesis of Murrayaquinone-A Derivatives and Investigation of Potential Anticancer Properties", 
  "url": "https://aperta.ulakbim.gov.tr/record/234308"
}