1 Ocak 2021 Dergi makalesi Açık Erişim

Cagatay, Elcin; Akyildiz, Volkan; Ergun, Yavuz; Kayali, Hulya Ayar

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/234308</identifier>
  <creators>
    <creator>
      <creatorName>Cagatay, Elcin</creatorName>
      <givenName>Elcin</givenName>
      <familyName>Cagatay</familyName>
    </creator>
    <creator>
      <creatorName>Akyildiz, Volkan</creatorName>
      <givenName>Volkan</givenName>
      <familyName>Akyildiz</familyName>
      <affiliation>Ataturk Univ, Fac Sci, Dept Chem, Erzurum, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ergun, Yavuz</creatorName>
      <givenName>Yavuz</givenName>
      <familyName>Ergun</familyName>
      <affiliation>Dokuz Eylul Univ, Fac Sci, Dept Chem, TR-35160 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kayali, Hulya Ayar</creatorName>
      <givenName>Hulya Ayar</givenName>
      <familyName>Kayali</familyName>
    </creator>
  </creators>
  <titles>
    <title>Synthesis Of Murrayaquinone-A Derivatives And Investigation Of Potential Anticancer Properties</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2021</publicationYear>
  <dates>
    <date dateType="Issued">2021-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/234308</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1002/cbdv.202100348</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">A series of novel murrayaquinone a derivatives were synthesized and their anti-cancer activity were evaluated on healthy colon cell lines (CCD-18Co), primary (Caco-2) and metastatic (DLD-1) colon cancer cell lines. The results showed that the cytotoxicity of murrayaquinone molecules is significantly high even in micromolar levels. The DNA binding, cell cycle arrest and metabolic activity studies of these molecules were also carried out and the results showed that these molecules induce apoptosis. In conclusion, the data support further studies on murrayaquinone derivatives toward selection of a candidate for cancer treatment.</description>
  </descriptions>
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