1 Ocak 2021 Dergi makalesi Açık Erişim

Tas, Meltem; Kucukaydin, Selcuk; Tel-Cayan, Gulsen; Duru, Mehmet Emin; Ozturk, Mehmet; Turk, Mustafa

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/232494</identifier>
  <creators>
    <creator>
      <creatorName>Tas, Meltem</creatorName>
      <givenName>Meltem</givenName>
      <familyName>Tas</familyName>
      <affiliation>Mugla Sitki Kocman Univ, Fac Sci, Dept Chem, TR-48000 Mugla, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kucukaydin, Selcuk</creatorName>
      <givenName>Selcuk</givenName>
      <familyName>Kucukaydin</familyName>
      <affiliation>Mugla Sitki Kocman Univ, Koycegiz Vocat Sch Hlth Serv, Dept Med Serv &amp; Tech, TR-48000 Koycegiz, Mugla, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Tel-Cayan, Gulsen</creatorName>
      <givenName>Gulsen</givenName>
      <familyName>Tel-Cayan</familyName>
      <affiliation>Mugla Sitki Kocman Univ, Mugla Vocat Sch, Dept Chem &amp; Chem Proc Technol, TR-48000 Mugla, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Duru, Mehmet Emin</creatorName>
      <givenName>Mehmet Emin</givenName>
      <familyName>Duru</familyName>
      <affiliation>Mugla Sitki Kocman Univ, Fac Sci, Dept Chem, TR-48000 Mugla, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozturk, Mehmet</creatorName>
      <givenName>Mehmet</givenName>
      <familyName>Ozturk</familyName>
      <affiliation>Mugla Sitki Kocman Univ, Fac Sci, Dept Chem, TR-48000 Mugla, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Turk, Mustafa</creatorName>
      <givenName>Mustafa</givenName>
      <familyName>Turk</familyName>
      <affiliation>Kirikkale Univ, Fac Engn &amp; Architecture, Dept Bioengn, TR-71450 Kirikkale, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Chemical Constituents And Their Bioactivities From Truffle Hysterangium Inflatum</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2021</publicationYear>
  <dates>
    <date dateType="Issued">2021-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/232494</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1007/s11694-021-00993-9</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Hysterangium inflatum is a truffle that grows naturally in the roots of Eucalyptus sp. and is distributed along the Mediterranean and Aegean coasts. Chemical investigation of the H. inflatum enabled to isolate of a new cerebroside, hysteroside (1), and seven known compounds namely, psyllic acid (2), brassicasterol (3), ergosterol (4), ergosterol d (5), ergosterol peroxide (6), ergosta-7,9,22-triene-3-O-beta-d-glucoside (7) and mannitol (8). IR, NMR, MS techniques were used for structural elucidation and supported with literature data. Antioxidant, cholinesterase, urease, and tyrosinase inhibitory and cytotoxic activities on MCF-7 breast, H-1299 lung cancer cells, and murine fibroblast (L929) non-cancerous cells of extracts and isolated compounds from H. inflatum were analyzed. All the isolated compounds, except compounds 2 and 8, displayed considerable cytotoxic activities against MCF-7 and H-1299 cancer cells. Compounds 1 (IC50: 18.11 mu g/mL) and 5 (IC50: 24.93 mu g/mL) were the most effective against MCF-7, while compounds 6 (IC50: 27.61 mu g/mL), 1 (IC50: 36.20 mu g/mL) and 5 (IC50: 38.62 mu g/mL) showed most potent toxicity against H-1299 and the extracts and compounds have no toxic effect on L929. Among the extracts, the methanol extract displayed the best antioxidant activity in all assays. Compound 1 exhibited highest enzyme inhibition activities with value of 58.71%, 52.84%, 45.37%, and 35.63%, against urease, tyrosinase, butrylcholinesterase (BChE), and acetylcholinesterase (AChE) enzymes at 100 mu g/mL concentration, among the isolated compounds. These results support that H. inflatum is a steroid-rich truffle and might be a potential source, especially for ergostane type steroids.</description>
  </descriptions>
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