1 Ocak 2021 Dergi makalesi Açık Erişim

Senol, Sefika Pinar; Temiz-Resitoglu, Meryem; Guden, Demet Sinem; Sari, Ayse Nihal; Sahan-Firat, Seyhan; Tunctan, Bahar

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        "affiliation": "Mersin Univ, Dept Pharmacol, Fac Pharm, Mersin, Turkey", 
        "name": "Senol, Sefika Pinar"
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      {
        "affiliation": "Mersin Univ, Dept Pharmacol, Fac Pharm, Mersin, Turkey", 
        "name": "Temiz-Resitoglu, Meryem"
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      {
        "affiliation": "Mersin Univ, Dept Pharmacol, Fac Pharm, Mersin, Turkey", 
        "name": "Guden, Demet Sinem"
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      {
        "affiliation": "Mersin Univ, Dept Pharmacol, Fac Pharm, Mersin, Turkey", 
        "name": "Sari, Ayse Nihal"
      }, 
      {
        "affiliation": "Mersin Univ, Dept Pharmacol, Fac Pharm, Mersin, Turkey", 
        "name": "Sahan-Firat, Seyhan"
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      {
        "affiliation": "Mersin Univ, Dept Pharmacol, Fac Pharm, Mersin, Turkey", 
        "name": "Tunctan, Bahar"
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    "description": "A selective RXR agonist, bexarotene, has been shown to have anti-inflammatory, anti-nociceptive, and neuroprotective effects in several models of numerous neurological diseases characterized by systemic inflammation. The mechanisms underlying these effects remains unknown. To elucidate these mechanisms, we investigated whether the TLR4/MyD88/TAK1/NF-kappa B/COX-2 signaling pathway in the CNS mediates the effect of bexarotene to prevent hyperalgesia in the LPS-induced inflammatory pain mouse model. The reaction time to thermal stimuli within 30 s was evaluated by the hot plate test in male mice treated with saline, LPS (10 mg/kg), DMSO, and/or bexarotene (0.1, 1, 3, or 10 mg/kg) after 6 h. The latency to the thermal stimulus (18.11 +/- 1.36 s) in the LPS-treated mice was significantly decreased by 30% compared with saline-treated mice (25.84 +/- 1.99 s). Treatment with bexarotene only at a dose of 10 mg/kg showed a significant increase in the latency by 22.49 +/- 1.00 s compared with LPS-treated mice. Bexarotene also prevented the reduction in RXR alpha protein expression associated with a rise in the expression of TLR4, MyD88, phosphorylated TAK1, NF-kappa B p65, phosphorylated NF-kappa B p65, COX-2, and IL-1 beta proteins, in addition to COX-2 activity and levels of PGE(2) and IL-1 beta in the brains and spinal cords of the LPS-treated animals. Likely, decreased activity of TLR4/MyD88/TAK1/NF-kappa B/COX-2 signaling pathway in addition to increased pro-inflammatory cytokine formation in the CNS of mice participates in the protective effect of bexarotene against hyperalgesia induced by LPS.", 
    "doi": "10.1007/s11064-020-03197-7", 
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    "journal": {
      "issue": "3", 
      "pages": "624-637", 
      "title": "NEUROCHEMICAL RESEARCH", 
      "volume": "46"
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      "id": "cc-by"
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      "title": "Dergi makalesi", 
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    "science_branches": [
      "Di\u011fer"
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    "title": "Suppression of TLR4/MyD88/TAK1/NF-kappa B/COX-2 Signaling Pathway in the Central Nervous System by Bexarotene, a Selective RXR Agonist, Prevents Hyperalgesia in the Lipopolysaccharide-Induced Pain Mouse Model"
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