1 Ocak 2021 Dergi makalesi Açık Erişim

Senol, Sefika Pinar; Temiz-Resitoglu, Meryem; Guden, Demet Sinem; Sari, Ayse Nihal; Sahan-Firat, Seyhan; Tunctan, Bahar

Citation Style Language JSON

{
  "DOI": "10.1007/s11064-020-03197-7", 
  "abstract": "A selective RXR agonist, bexarotene, has been shown to have anti-inflammatory, anti-nociceptive, and neuroprotective effects in several models of numerous neurological diseases characterized by systemic inflammation. The mechanisms underlying these effects remains unknown. To elucidate these mechanisms, we investigated whether the TLR4/MyD88/TAK1/NF-kappa B/COX-2 signaling pathway in the CNS mediates the effect of bexarotene to prevent hyperalgesia in the LPS-induced inflammatory pain mouse model. The reaction time to thermal stimuli within 30 s was evaluated by the hot plate test in male mice treated with saline, LPS (10 mg/kg), DMSO, and/or bexarotene (0.1, 1, 3, or 10 mg/kg) after 6 h. The latency to the thermal stimulus (18.11 +/- 1.36 s) in the LPS-treated mice was significantly decreased by 30% compared with saline-treated mice (25.84 +/- 1.99 s). Treatment with bexarotene only at a dose of 10 mg/kg showed a significant increase in the latency by 22.49 +/- 1.00 s compared with LPS-treated mice. Bexarotene also prevented the reduction in RXR alpha protein expression associated with a rise in the expression of TLR4, MyD88, phosphorylated TAK1, NF-kappa B p65, phosphorylated NF-kappa B p65, COX-2, and IL-1 beta proteins, in addition to COX-2 activity and levels of PGE(2) and IL-1 beta in the brains and spinal cords of the LPS-treated animals. Likely, decreased activity of TLR4/MyD88/TAK1/NF-kappa B/COX-2 signaling pathway in addition to increased pro-inflammatory cytokine formation in the CNS of mice participates in the protective effect of bexarotene against hyperalgesia induced by LPS.", 
  "author": [
    {
      "family": "Senol", 
      "given": " Sefika Pinar"
    }, 
    {
      "family": "Temiz-Resitoglu", 
      "given": " Meryem"
    }, 
    {
      "family": "Guden", 
      "given": " Demet Sinem"
    }, 
    {
      "family": "Sari", 
      "given": " Ayse Nihal"
    }, 
    {
      "family": "Sahan-Firat", 
      "given": " Seyhan"
    }, 
    {
      "family": "Tunctan", 
      "given": " Bahar"
    }
  ], 
  "container_title": "NEUROCHEMICAL RESEARCH", 
  "id": "231630", 
  "issue": "3", 
  "issued": {
    "date-parts": [
      [
        2021, 
        1, 
        1
      ]
    ]
  }, 
  "page": "624-637", 
  "title": "Suppression of TLR4/MyD88/TAK1/NF-kappa B/COX-2 Signaling Pathway in the Central Nervous System by Bexarotene, a Selective RXR Agonist, Prevents Hyperalgesia in the Lipopolysaccharide-Induced Pain Mouse Model", 
  "type": "article-journal", 
  "volume": "46"
}