1 Ocak 2022 Dergi makalesi Açık Erişim

Uygun, Meltem Tan; Amudi, Karina; Turacli, Irem Dogan; Menges, Nurettin

Dublin Core

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  <dc:creator>Uygun, Meltem Tan</dc:creator>
  <dc:creator>Amudi, Karina</dc:creator>
  <dc:creator>Turacli, Irem Dogan</dc:creator>
  <dc:creator>Menges, Nurettin</dc:creator>
  <dc:date>2022-01-01</dc:date>
  <dc:description>Starting from the 3,5-dimethyl pyrazole ring and acetophenone derivatives, five different N-propargylated C-3 substituted pyrazoles were obtained. These derivatives were reacted with different amine derivatives using Cs2CO3 in methanol and 11 different pyrazolo [1,5-a] pyrazine-4(5H)-one derivatives were obtained, which are not found in the literature. The cytotoxic effects of these derivatives in the A549 cell line were investigated. The 160 mu M concentration of two derivatives was found to increase cell death rate to 50%, and two derivatives increased cell death rate by up to 40%. The structure-activity relationship (SAR) study revealed an amide group with a long alkyl chain and benzene ring with a p-CF3 group could be important for efficiency. With theoretical ADMET studies of pyrazolopyrazine derivatives, pharmacokinetic phases were predicted to be suitable.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/231626</dc:identifier>
  <dc:identifier>oai:aperta.ulakbim.gov.tr:231626</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>MOLECULAR DIVERSITY 26(1) 113-124</dc:source>
  <dc:title>A new synthetic approach for pyrazolo[1,5-a]pyrazine-4(5H)-one derivatives and their antiproliferative effects on lung adenocarcinoma cell line</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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