1 Ocak 2022 Dergi makalesi Açık Erişim

Uygun, Meltem Tan; Amudi, Karina; Turacli, Irem Dogan; Menges, Nurettin

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        "name": "Uygun, Meltem Tan"
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      {
        "name": "Amudi, Karina"
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      {
        "affiliation": "Ufuk Univ, Fac Med, Dept Med Biol, TR-06520 Ankara, Turkey", 
        "name": "Turacli, Irem Dogan"
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      {
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    "description": "Starting from the 3,5-dimethyl pyrazole ring and acetophenone derivatives, five different N-propargylated C-3 substituted pyrazoles were obtained. These derivatives were reacted with different amine derivatives using Cs2CO3 in methanol and 11 different pyrazolo [1,5-a] pyrazine-4(5H)-one derivatives were obtained, which are not found in the literature. The cytotoxic effects of these derivatives in the A549 cell line were investigated. The 160 mu M concentration of two derivatives was found to increase cell death rate to 50%, and two derivatives increased cell death rate by up to 40%. The structure-activity relationship (SAR) study revealed an amide group with a long alkyl chain and benzene ring with a p-CF3 group could be important for efficiency. With theoretical ADMET studies of pyrazolopyrazine derivatives, pharmacokinetic phases were predicted to be suitable.", 
    "doi": "10.1007/s11030-020-10161-8", 
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      "issue": "1", 
      "pages": "113-124", 
      "title": "MOLECULAR DIVERSITY", 
      "volume": "26"
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    "publication_date": "2022-01-01", 
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    "title": "A new synthetic approach for pyrazolo[1,5-a]pyrazine-4(5H)-one derivatives and their antiproliferative effects on lung adenocarcinoma cell line"
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