1 Ocak 2021 Dergi makalesi Açık Erişim

Kanova, Nilay; Dundar, Buse Aysen; Kelgokmen, Yilmaz; Zora, Metin

Dublin Core

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<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Kanova, Nilay</dc:creator>
  <dc:creator>Dundar, Buse Aysen</dc:creator>
  <dc:creator>Kelgokmen, Yilmaz</dc:creator>
  <dc:creator>Zora, Metin</dc:creator>
  <dc:date>2021-01-01</dc:date>
  <dc:description>A one pot two step protocol for the synthesis of 2-acetyl-1H-pyrroles from N-propargylic beta-enaminones was described. When treated with zinc chloride in refluxing chloroform, N-propargylic beta-enaminones produced in situ 2-methylene-2,3-dihydro-1,4-oxazepines, which, upon further refluxing in methanol with zinc chloride, afforded 2-acetyl-1H-pyrroles. The process was found to be general for a wide variety of N-propargylic beta-enaminones and yielded a diverse range of 2-acetyl-1H-pyrroles in good to high yields with large substrate scope and good functional group tolerance. This operationally easy method may provide a rapid access to functionalized 2-acetyl-1H-pyrroles of pharmacological interest.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/231356</dc:identifier>
  <dc:identifier>oai:aperta.ulakbim.gov.tr:231356</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>JOURNAL OF ORGANIC CHEMISTRY 86(9) 6289-6304</dc:source>
  <dc:title>One-Pot Synthesis of 2-Acety1-1H-pyrroles from N-Propargylic beta-Enaminones via Intermediacy of 1,4-Oxazepines</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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