Dergi makalesi Açık Erişim
Han, Sevtap; Cicek, Ali Fuat; Tokmak, Aytekin; Ustun, Tugce Yildirir; Gokay, Nilufer Ercan; Uludag, Mecit Orhan; Demirel, Murside Ayse
<?xml version='1.0' encoding='UTF-8'?> <record xmlns="http://www.loc.gov/MARC21/slim"> <leader>00000nam##2200000uu#4500</leader> <datafield tag="245" ind1=" " ind2=" "> <subfield code="a">Effects of Resveratrol on Receptor Expression and Serum Levels of Estrogen and Progesterone in the Rat Endometritis Model</subfield> </datafield> <datafield tag="909" ind1="C" ind2="4"> <subfield code="p">REPRODUCTIVE SCIENCES</subfield> <subfield code="v">28</subfield> <subfield code="n">9</subfield> <subfield code="c">2610-2622</subfield> </datafield> <controlfield tag="001">230658</controlfield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="520" ind1=" " ind2=" "> <subfield code="a">Endometritis is characterized by inflammation of the endometrial lining that leads to reduced reproductive potential. Restoring the impaired hormonal balance is an important component of endometritis treatment. The purpose of the current study was to evaluate the effects of resveratrol on estrogen and progesterone hormone status in endometritis. Mature female Sprague Dawley rats were used, and endometritis was induced by intrauterine infusion of Escherichia coli. Animals were treated with resveratrol alone or combined with marbofloxacin. Compared to the non-treated endometritis group, resveratrol treatment reduced serum oestradiol levels, increased serum progesterone levels, enhanced estrogen receptor (ER) expression in the uterine stroma, decreased ESR1 gene expression, and raised ESR2 gene expression. Resveratrol administration combined with marbofloxacin also increased ER expression in the uterine gland and progesterone receptor expression in the uterine epithelium. The findings of this study suggest that the actions of resveratrol on progesterone levels and estrogen receptor expression might be responsible for its beneficial effect in rats with endometritis.</subfield> </datafield> <datafield tag="650" ind1="1" ind2="7"> <subfield code="2">opendefinition.org</subfield> <subfield code="a">cc-by</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Gulhane Res & Educ Hosp, Dept Pathol, TR-06010 Ankara, Turkey</subfield> <subfield code="a">Cicek, Ali Fuat</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Zekai Tahir Burak Womens Hlth Res & Educ Hosp, Dept Obstet & Gynecol, TR-06230 Ankara, Turkey</subfield> <subfield code="a">Tokmak, Aytekin</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Ankara Univ, Fac Vet, Dept Microbiol, TR-06110 Ankara, Turkey</subfield> <subfield code="a">Ustun, Tugce Yildirir</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Zekai Tahir Burak Womens Hlth Res & Educ Hosp, Dept Obstet & Gynecol, TR-06230 Ankara, Turkey</subfield> <subfield code="a">Gokay, Nilufer Ercan</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Gazi Univ, Fac Pharm, Dept Pharmacol, TR-06330 Ankara, Turkey</subfield> <subfield code="a">Uludag, Mecit Orhan</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Gazi Univ, Fac Pharm, Dept Pharmacol, Lab Anim Care & Res Unit, TR-06330 Ankara, Turkey</subfield> <subfield code="a">Demirel, Murside Ayse</subfield> </datafield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="b">article</subfield> <subfield code="a">publication</subfield> </datafield> <datafield tag="542" ind1=" " ind2=" "> <subfield code="l">open</subfield> </datafield> <datafield tag="100" ind1=" " ind2=" "> <subfield code="u">Gazi Univ, Fac Pharm, Dept Pharmacol, TR-06330 Ankara, Turkey</subfield> <subfield code="a">Han, Sevtap</subfield> </datafield> <datafield tag="260" ind1=" " ind2=" "> <subfield code="c">2021-01-01</subfield> </datafield> <controlfield tag="005">20221007075620.0</controlfield> <datafield tag="909" ind1="C" ind2="O"> <subfield code="o">oai:aperta.ulakbim.gov.tr:230658</subfield> <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="856" ind1="4" ind2=" "> <subfield code="z">md5:259807e3d560510477f4e74d0b43b3f0</subfield> <subfield code="s">250</subfield> <subfield code="u">https://aperta.ulakbim.gov.trrecord/230658/files/bib-0e2fa5b1-aa1f-44eb-8c68-805a343a44c7.txt</subfield> </datafield> <datafield tag="540" ind1=" " ind2=" "> <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield> <subfield code="a">Creative Commons Attribution</subfield> </datafield> <datafield tag="024" ind1=" " ind2=" "> <subfield code="a">10.1007/s43032-021-00586-3</subfield> <subfield code="2">doi</subfield> </datafield> </record>
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