1 Ocak 2021 Dergi makalesi Açık Erişim

Han, Sevtap; Cicek, Ali Fuat; Tokmak, Aytekin; Ustun, Tugce Yildirir; Gokay, Nilufer Ercan; Uludag, Mecit Orhan; Demirel, Murside Ayse

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/230658</identifier>
  <creators>
    <creator>
      <creatorName>Han, Sevtap</creatorName>
      <givenName>Sevtap</givenName>
      <familyName>Han</familyName>
      <affiliation>Gazi Univ, Fac Pharm, Dept Pharmacol, TR-06330 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Cicek, Ali Fuat</creatorName>
      <givenName>Ali Fuat</givenName>
      <familyName>Cicek</familyName>
      <affiliation>Gulhane Res &amp; Educ Hosp, Dept Pathol, TR-06010 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Tokmak, Aytekin</creatorName>
      <givenName>Aytekin</givenName>
      <familyName>Tokmak</familyName>
      <affiliation>Zekai Tahir Burak Womens Hlth Res &amp; Educ Hosp, Dept Obstet &amp; Gynecol, TR-06230 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ustun, Tugce Yildirir</creatorName>
      <givenName>Tugce Yildirir</givenName>
      <familyName>Ustun</familyName>
      <affiliation>Ankara Univ, Fac Vet, Dept Microbiol, TR-06110 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Gokay, Nilufer Ercan</creatorName>
      <givenName>Nilufer Ercan</givenName>
      <familyName>Gokay</familyName>
      <affiliation>Zekai Tahir Burak Womens Hlth Res &amp; Educ Hosp, Dept Obstet &amp; Gynecol, TR-06230 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Uludag, Mecit Orhan</creatorName>
      <givenName>Mecit Orhan</givenName>
      <familyName>Uludag</familyName>
      <affiliation>Gazi Univ, Fac Pharm, Dept Pharmacol, TR-06330 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Demirel, Murside Ayse</creatorName>
      <givenName>Murside Ayse</givenName>
      <familyName>Demirel</familyName>
      <affiliation>Gazi Univ, Fac Pharm, Dept Pharmacol, Lab Anim Care &amp; Res Unit, TR-06330 Ankara, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Effects Of Resveratrol On Receptor Expression And Serum Levels Of Estrogen And Progesterone In The Rat Endometritis Model</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2021</publicationYear>
  <dates>
    <date dateType="Issued">2021-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/230658</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1007/s43032-021-00586-3</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Endometritis is characterized by inflammation of the endometrial lining that leads to reduced reproductive potential. Restoring the impaired hormonal balance is an important component of endometritis treatment. The purpose of the current study was to evaluate the effects of resveratrol on estrogen and progesterone hormone status in endometritis. Mature female Sprague Dawley rats were used, and endometritis was induced by intrauterine infusion of Escherichia coli. Animals were treated with resveratrol alone or combined with marbofloxacin. Compared to the non-treated endometritis group, resveratrol treatment reduced serum oestradiol levels, increased serum progesterone levels, enhanced estrogen receptor (ER) expression in the uterine stroma, decreased ESR1 gene expression, and raised ESR2 gene expression. Resveratrol administration combined with marbofloxacin also increased ER expression in the uterine gland and progesterone receptor expression in the uterine epithelium. The findings of this study suggest that the actions of resveratrol on progesterone levels and estrogen receptor expression might be responsible for its beneficial effect in rats with endometritis.</description>
  </descriptions>
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