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An update comprehensive review on the status of COVID-19: vaccines, drugs, variants and neurological symptoms

Ebru; Salih; Tuğba; Ömer Faruk; Öznur Özge; Tuğçe; Mesut; Muhsin


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    "creators": [
      {
        "affiliation": "\u00d6ZKAN OKTAY", 
        "name": "Ebru", 
        "orcid": "0000-0002-0395-9845"
      }, 
      {
        "affiliation": "TUNCAY", 
        "name": "Salih", 
        "orcid": "0000-0003-3838-5228"
      }, 
      {
        "affiliation": "KAMAN", 
        "name": "Tu\u011fba", 
        "orcid": "0000-0002-5885-0193"
      }, 
      {
        "affiliation": "KARASAKAL", 
        "name": "\u00d6mer Faruk", 
        "orcid": "0000-0001-7803-3249"
      }, 
      {
        "affiliation": "\u00d6ZCAN", 
        "name": "\u00d6znur \u00d6zge", 
        "orcid": "0000-0001-8992-0556"
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      {
        "affiliation": "SOYLAMI\u015e", 
        "name": "Tu\u011f\u00e7e", 
        "orcid": "0000-0002-4663-897X"
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      {
        "affiliation": "KARAHAN", 
        "name": "Mesut", 
        "orcid": "0000-0002-8971-678X"
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      {
        "affiliation": "KONUK", 
        "name": "Muhsin", 
        "orcid": "0000-0002-6651-718X"
      }
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    "description": "<p>Various recently reported mutant variants, candidate and urgently approved current vaccines against severe acute respiratory&nbsp;syndrome coronavirus 2 (SARS-CoV-2), many current situations with severe neurological damage and symptoms as well as respiratory&nbsp;tract disorders have begun to be reported. In particular, drug, vaccine, and neutralizing monoclonal antibodies (mAbs) have been&nbsp;developed and are currently being evaluated in clinical trials. Here, we review lessons learned from the use of novel mutant variants&nbsp;of the COVID-19 virus, immunization, new drug solutions, and antibody therapies for infections. Next, we focus on the B 1.1.7, B&nbsp;1.351, P.1, and B.1.617 lineages or variants of concern that have been reported worldwide, the new manifestations of neurological&nbsp;manifestations, the current therapeutic drug targets for its treatment, vaccine candidates and their efficacy, implantation of convalescent&nbsp;plasma, and neutralization of mAbs. We review specific clinical questions, including many emerging neurological effects and respiratory&nbsp;tract injuries, as well as new potential biomarkers, new studies in addition to known therapeutics, and chronic diseases of vaccines&nbsp;that have received immediate approval. To answer these questions, further understanding of the burden kinetics of COVID-19 and its&nbsp;correlation with neurological clinical outcomes, endogenous antibody responses to vaccines, pharmacokinetics of neutralizing mAbs,&nbsp;and action against emerging viral mutant variants is needed.</p>", 
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    "journal": {
      "issue": "SI-1", 
      "pages": "342-357", 
      "title": "Turkish Journal of Biology", 
      "volume": "45"
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    "keywords": [
      "COVID-19", 
      "variants", 
      "neurological symptoms", 
      "drugs", 
      "vaccines", 
      "neutralizing antibodies", 
      "SARS-CoV-2"
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      "title": "Dergi makalesi", 
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    "science_branches": [
      "Temel Bilimler > Ya\u015fam Bilimleri > Molek\u00fcler Biyoloji ve Genetik"
    ], 
    "title": "An update comprehensive review on the status of COVID-19: vaccines, drugs, variants and neurological symptoms"
  }, 
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    34
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