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An update comprehensive review on the status of COVID-19: vaccines, drugs, variants and neurological symptoms

Ebru; Salih; Tuğba; Ömer Faruk; Öznur Özge; Tuğçe; Mesut; Muhsin


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{
  "DOI": "10.3906/biy-2106-23", 
  "abstract": "<p>Various recently reported mutant variants, candidate and urgently approved current vaccines against severe acute respiratory&nbsp;syndrome coronavirus 2 (SARS-CoV-2), many current situations with severe neurological damage and symptoms as well as respiratory&nbsp;tract disorders have begun to be reported. In particular, drug, vaccine, and neutralizing monoclonal antibodies (mAbs) have been&nbsp;developed and are currently being evaluated in clinical trials. Here, we review lessons learned from the use of novel mutant variants&nbsp;of the COVID-19 virus, immunization, new drug solutions, and antibody therapies for infections. Next, we focus on the B 1.1.7, B&nbsp;1.351, P.1, and B.1.617 lineages or variants of concern that have been reported worldwide, the new manifestations of neurological&nbsp;manifestations, the current therapeutic drug targets for its treatment, vaccine candidates and their efficacy, implantation of convalescent&nbsp;plasma, and neutralization of mAbs. We review specific clinical questions, including many emerging neurological effects and respiratory&nbsp;tract injuries, as well as new potential biomarkers, new studies in addition to known therapeutics, and chronic diseases of vaccines&nbsp;that have received immediate approval. To answer these questions, further understanding of the burden kinetics of COVID-19 and its&nbsp;correlation with neurological clinical outcomes, endogenous antibody responses to vaccines, pharmacokinetics of neutralizing mAbs,&nbsp;and action against emerging viral mutant variants is needed.</p>", 
  "author": [
    {
      "family": "Ebru"
    }, 
    {
      "family": "Salih"
    }, 
    {
      "family": "Tu\u011fba"
    }, 
    {
      "family": "\u00d6mer Faruk"
    }, 
    {
      "family": "\u00d6znur \u00d6zge"
    }, 
    {
      "family": "Tu\u011f\u00e7e"
    }, 
    {
      "family": "Mesut"
    }, 
    {
      "family": "Muhsin"
    }
  ], 
  "container_title": "Turkish Journal of Biology", 
  "id": "227979", 
  "issue": "SI-1", 
  "issued": {
    "date-parts": [
      [
        2021, 
        8, 
        30
      ]
    ]
  }, 
  "page": "342-357", 
  "title": "An update comprehensive review on the status of COVID-19: vaccines, drugs, variants and neurological symptoms", 
  "type": "article-journal", 
  "volume": "45"
}
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