1 Ocak 2011 Dergi makalesi Açık Erişim

Selek, Sahabettin; Karapehlivan, Mahmut; Citil, Mehmet; Tunca, Recai; Uzlu, Erdogan; Erdogan, Hidayet Metin

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  <dc:creator>Selek, Sahabettin</dc:creator>
  <dc:creator>Karapehlivan, Mahmut</dc:creator>
  <dc:creator>Citil, Mehmet</dc:creator>
  <dc:creator>Tunca, Recai</dc:creator>
  <dc:creator>Uzlu, Erdogan</dc:creator>
  <dc:creator>Erdogan, Hidayet Metin</dc:creator>
  <dc:date>2011-01-01</dc:date>
  <dc:description>The scope of this study was to determine the effect of gemfibrozil, l-carnitine and their combination on paraoxonase/arylesterase activity, oxidative/anti-oxidative parameters and hepatosteatosis in rabbits on fat-rich diet. The study involved 35 New Zealand albino white rabbits. Animals were equally divided into 5 groups (n=7); group I: control (standard diet), group II: rabbits received only fat-rich diet, group III: rabbits received fat-rich diet plus gemfibrozil (100 mg/kg/day, oral), group IV: rabbits received fat-rich diet plus L-carnitine groups (200 mg/kg/day, oral), and group V: rabbits received fat-rich diet plus the combination of gemfibrozil (100 mg/kg/day, oral) and L-carnitine (200 mg/kg/day, oral) for 9 weeks. The results revealed marked increases in ALT and AST activities in group III (P &lt; 0.05) throughout the experiment and a gradual increase in activities of paraoxonase/arylesterase in group III, IV and V when compared to group I and II (P &lt; 0.05) and a decrease in OSI and TOS levels in group IV and V when compared to group I and II (P &lt; 0.05) over the experimental period. A significant negative correlation between serum OSI and paraoxonase and arylesterase activities in group IV (r=-0.36, P &lt; 0.012 and r=-0.41, P &lt; 0.009, respectively) and V (r=-0.31, P &lt; 0.022 and r=-0.37, P &lt; 0.014, respectively). A similar correlation was determined for liver samples. Changes in paraoxonase and arylesterase activity at 0, 3, 6 and 9 weeks were positivelly correlated with the changes in high density lipoprotein-cholesterol (HDL-C) in group III (r=0.63, P &lt; 0.001 and r=0.57, P &lt; 0.003; respectively). The present study disclosed hepatosteatosis and hyperlipidemi due to fat-rich diet in rabbits, and treatment of gemfibrozil is required in order to increase PON1 activity.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/19427</dc:identifier>
  <dc:identifier>oai:zenodo.org:19427</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI 17(2) 183-190</dc:source>
  <dc:title>Effects of Gemfibrozil and L-carnitine on PON1 Activity, Oxidative/Anti-Oxidative Parameters and Hepatosteatosis in Rabbits Feed With Fat-Rich Diet</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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