1 Ocak 2011 Dergi makalesi Açık Erişim

Selek, Sahabettin; Karapehlivan, Mahmut; Citil, Mehmet; Tunca, Recai; Uzlu, Erdogan; Erdogan, Hidayet Metin

DataCite XML

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/19427</identifier>
  <creators>
    <creator>
      <creatorName>Selek, Sahabettin</creatorName>
      <givenName>Sahabettin</givenName>
      <familyName>Selek</familyName>
      <affiliation>Harran Univ, Sch Med, Dept Clin Biochem, TR-63100 Sanliurfa, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Karapehlivan, Mahmut</creatorName>
      <givenName>Mahmut</givenName>
      <familyName>Karapehlivan</familyName>
      <affiliation>Kafkas Univ, Fac Vet Med, Dept Biochem, TR-36100 Kars, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Citil, Mehmet</creatorName>
      <givenName>Mehmet</givenName>
      <familyName>Citil</familyName>
      <affiliation>Kafkas Univ, Fac Vet Med, Dept Internal Med, TR-36100 Kars, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Tunca, Recai</creatorName>
      <givenName>Recai</givenName>
      <familyName>Tunca</familyName>
      <affiliation>Adnan Menderes Univ, Fac Vet Med, Dept Pathol, TR-09100 Aydin, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Uzlu, Erdogan</creatorName>
      <givenName>Erdogan</givenName>
      <familyName>Uzlu</familyName>
      <affiliation>Kafkas Univ, Fac Vet Med, Dept Internal Med, TR-36100 Kars, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Erdogan, Hidayet Metin</creatorName>
      <givenName>Hidayet Metin</givenName>
      <familyName>Erdogan</familyName>
      <affiliation>Kafkas Univ, Fac Vet Med, Dept Internal Med, TR-36100 Kars, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Effects Of Gemfibrozil And L-Carnitine On Pon1 Activity, Oxidative/Anti-Oxidative Parameters And Hepatosteatosis In Rabbits Feed With Fat-Rich Diet</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2011</publicationYear>
  <dates>
    <date dateType="Issued">2011-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/19427</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsVersionOf">10.81043/aperta.19426</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.81043/aperta.19427</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">The scope of this study was to determine the effect of gemfibrozil, l-carnitine and their combination on paraoxonase/arylesterase activity, oxidative/anti-oxidative parameters and hepatosteatosis in rabbits on fat-rich diet. The study involved 35 New Zealand albino white rabbits. Animals were equally divided into 5 groups (n=7); group I: control (standard diet), group II: rabbits received only fat-rich diet, group III: rabbits received fat-rich diet plus gemfibrozil (100 mg/kg/day, oral), group IV: rabbits received fat-rich diet plus L-carnitine groups (200 mg/kg/day, oral), and group V: rabbits received fat-rich diet plus the combination of gemfibrozil (100 mg/kg/day, oral) and L-carnitine (200 mg/kg/day, oral) for 9 weeks. The results revealed marked increases in ALT and AST activities in group III (P &amp;lt; 0.05) throughout the experiment and a gradual increase in activities of paraoxonase/arylesterase in group III, IV and V when compared to group I and II (P &amp;lt; 0.05) and a decrease in OSI and TOS levels in group IV and V when compared to group I and II (P &amp;lt; 0.05) over the experimental period. A significant negative correlation between serum OSI and paraoxonase and arylesterase activities in group IV (r=-0.36, P &amp;lt; 0.012 and r=-0.41, P &amp;lt; 0.009, respectively) and V (r=-0.31, P &amp;lt; 0.022 and r=-0.37, P &amp;lt; 0.014, respectively). A similar correlation was determined for liver samples. Changes in paraoxonase and arylesterase activity at 0, 3, 6 and 9 weeks were positivelly correlated with the changes in high density lipoprotein-cholesterol (HDL-C) in group III (r=0.63, P &amp;lt; 0.001 and r=0.57, P &amp;lt; 0.003; respectively). The present study disclosed hepatosteatosis and hyperlipidemi due to fat-rich diet in rabbits, and treatment of gemfibrozil is required in order to increase PON1 activity.</description>
  </descriptions>
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