1 Ocak 2013 Dergi makalesi Açık Erişim

Kayhan, Gulay Erdogan; Gul, Mehmet; Kayhan, Basak; Gedik, Ender; Ozgul, Ulku; Kurtoglu, Elcin Latife; Durmus, Mahmut; Ersoy, Mehmet Ozcan

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/17121</identifier>
  <creators>
    <creator>
      <creatorName>Kayhan, Gulay Erdogan</creatorName>
      <givenName>Gulay Erdogan</givenName>
      <familyName>Kayhan</familyName>
      <affiliation>Inonu Univ, Turgut Ozal Med Ctr, Fac Med, Dept Anesthesiol &amp; Reanimat, TR-44100 Malatya, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Gul, Mehmet</creatorName>
      <givenName>Mehmet</givenName>
      <familyName>Gul</familyName>
      <affiliation>Inonu Univ, Turgut Ozal Med Ctr, Fac Med, Dept Histol &amp; Embryol, TR-44100 Malatya, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kayhan, Basak</creatorName>
      <givenName>Basak</givenName>
      <familyName>Kayhan</familyName>
      <affiliation>Inonu Univ, Turgut Ozal Med Ctr, Fac Med, Dept Med Biol &amp; Genet, TR-44100 Malatya, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Gedik, Ender</creatorName>
      <givenName>Ender</givenName>
      <familyName>Gedik</familyName>
      <affiliation>Inonu Univ, Turgut Ozal Med Ctr, Fac Med, Dept Anesthesiol &amp; Reanimat, TR-44100 Malatya, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozgul, Ulku</creatorName>
      <givenName>Ulku</givenName>
      <familyName>Ozgul</familyName>
      <affiliation>Inonu Univ, Turgut Ozal Med Ctr, Fac Med, Dept Anesthesiol &amp; Reanimat, TR-44100 Malatya, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kurtoglu, Elcin Latife</creatorName>
      <givenName>Elcin Latife</givenName>
      <familyName>Kurtoglu</familyName>
      <affiliation>Inonu Univ, Turgut Ozal Med Ctr, Fac Med, Dept Med Biol &amp; Genet, TR-44100 Malatya, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Durmus, Mahmut</creatorName>
      <givenName>Mahmut</givenName>
      <familyName>Durmus</familyName>
      <affiliation>Inonu Univ, Turgut Ozal Med Ctr, Fac Med, Dept Anesthesiol &amp; Reanimat, TR-44100 Malatya, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ersoy, Mehmet Ozcan</creatorName>
      <givenName>Mehmet Ozcan</givenName>
      <familyName>Ersoy</familyName>
      <affiliation>Inonu Univ, Turgut Ozal Med Ctr, Fac Med, Dept Anesthesiol &amp; Reanimat, TR-44100 Malatya, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Dexmedetomidine Ameliorates Tnbs-Induced Colitis By Inducing Immunomodulator Effect</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2013</publicationYear>
  <dates>
    <date dateType="Issued">2013-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/17121</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.jss.2013.03.028</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Background: Since sedatives are often administered to immune-compromised and critically ill patients, our understanding of immunomodulation by sedation will be critical. Dexmedetomidine, a selective alpha(2)-adrenergic receptor agonist, is often used for sedation and analgesia especially in intensive care units. There are conflicting and little data concerning both the effect and the mechanism of dexmedetomidine on immune response. In our study, we aimed to investigate the effect of dexmedetomidine on immune system at two different doses (5 mu g.kg(-1) and 30 mu g.kg(-1)) during inflammatory bowel disease by using an experimental model, which resembles both systemic and local inflammation.</description>
  </descriptions>
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