1 Ocak 2013 Dergi makalesi Açık Erişim

Topuzogullari, Murat; Koc, Rabia Cakir; Isoglu, Sevil Dincer; Bagirova, Melahat; Akdeste, Zeynep; Elcicek, Serhat; Oztel, Olga N.; Baydar, Serap Yesilkir; Ates, Sezen Canim; Allahverdiyev, Adil M.

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/16225</identifier>
  <creators>
    <creator>
      <creatorName>Topuzogullari, Murat</creatorName>
      <givenName>Murat</givenName>
      <familyName>Topuzogullari</familyName>
      <affiliation>Yildiz Tech Univ, Dept Bioengn, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Koc, Rabia Cakir</creatorName>
      <givenName>Rabia Cakir</givenName>
      <familyName>Koc</familyName>
      <affiliation>Yeni Yuzyil Univ, Dept Biomed Engn, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Isoglu, Sevil Dincer</creatorName>
      <givenName>Sevil Dincer</givenName>
      <familyName>Isoglu</familyName>
      <affiliation>Yildiz Tech Univ, Dept Bioengn, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Bagirova, Melahat</creatorName>
      <givenName>Melahat</givenName>
      <familyName>Bagirova</familyName>
      <affiliation>Yildiz Tech Univ, Dept Bioengn, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Akdeste, Zeynep</creatorName>
      <givenName>Zeynep</givenName>
      <familyName>Akdeste</familyName>
      <affiliation>Yildiz Tech Univ, Dept Bioengn, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Elcicek, Serhat</creatorName>
      <givenName>Serhat</givenName>
      <familyName>Elcicek</familyName>
      <affiliation>Firat Univ, Dept Bioengn, TR-23169 Elazig, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Oztel, Olga N.</creatorName>
      <givenName>Olga N.</givenName>
      <familyName>Oztel</familyName>
      <affiliation>Yildiz Tech Univ, Dept Bioengn, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Baydar, Serap Yesilkir</creatorName>
      <givenName>Serap Yesilkir</givenName>
      <familyName>Baydar</familyName>
      <affiliation>Yildiz Tech Univ, Dept Bioengn, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ates, Sezen Canim</creatorName>
      <givenName>Sezen Canim</givenName>
      <familyName>Ates</familyName>
      <affiliation>Yildiz Tech Univ, Dept Bioengn, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Allahverdiyev, Adil M.</creatorName>
      <givenName>Adil M.</givenName>
      <familyName>Allahverdiyev</familyName>
      <affiliation>Yildiz Tech Univ, Dept Bioengn, Istanbul, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Conjugation, Characterization And Toxicity Of Lipophosphoglycan-Polyacrylic Acid Conjugate For Vaccination Against Leishmaniasis</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2013</publicationYear>
  <dates>
    <date dateType="Issued">2013-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/16225</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1186/1423-0127-20-35</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Research on the conjugates of synthetic polyelectrolytes with antigenic molecules, such as proteins, peptides, or carbohydrates, is an attractive area due to their highly immunogenic character in comparison to classical adjuvants. For example, polyacrylic acid (PAA) is a weak polyelectrolyte and has been used in several biomedical applications such as immunological studies, drug delivery, and enzyme immobilization. However, to our knowledge, there are no studies that document immune-stimulant properties of PAA in Leishmania infection. Therefore, we aimed to develop a potential vaccine candidate against leishmaniasis by covalently conjugating PAA with an immunologically vital molecule of lipophosphoglycan (LPG) found in Leishmania parasites. In the study, LPG and PAA were conjugated by a multi-step procedure, and final products were analyzed with GPC and MALDI-TOF MS techniques. In cytotoxicity experiments, LPG-PAA conjugates did not indicate toxic effects on L929 and J774 murine macrophage cells. We assume that LPG-PAA conjugate can be a potential vaccine candidate, and will be immunologically characterized in further studies to prove its potential.</description>
  </descriptions>
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