1 Ocak 2020 Dergi makalesi Açık Erişim

Dincer, Tuba; Er, Asiye Busra Boz; Er, Idris; Toraman, Bayram; Yildiz, Gokhan; Kalay, Ersan

MARC21 XML

<?xml version='1.0' encoding='UTF-8'?>
<record xmlns="http://www.loc.gov/MARC21/slim">
  <leader>00000nam##2200000uu#4500</leader>
  <datafield tag="245" ind1=" " ind2=" ">
    <subfield code="a">RIPK4 suppresses the TGF-beta 1 signaling pathway in HaCaT cells</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="4">
    <subfield code="p">CELL BIOLOGY INTERNATIONAL</subfield>
    <subfield code="v">44</subfield>
    <subfield code="n">3</subfield>
    <subfield code="c">848-860</subfield>
  </datafield>
  <controlfield tag="001">11493</controlfield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">user-tubitak-destekli-proje-yayinlari</subfield>
  </datafield>
  <datafield tag="520" ind1=" " ind2=" ">
    <subfield code="a">Receptor-interacting serine/threonine kinase 4 (RIPK4) and transforming growth factor-beta 1 (TGF-beta 1) play critical roles in the development and maintenance of the epidermis. A negative correlation between the expression patterns of RIPK4 and TGF-beta signaling during epidermal homeostasis-related events and suppression of RIPK4 expression by TGF-beta 1 in keratinocyte cell lines suggest the presence of a negative regulatory loop between the two factors. So far, RIPK4 has been shown to regulate nuclear factor-kappa B (NF-kappa B), protein kinase C (PKC), wingless-type MMTV integration site family (Wnt), and (mitogen-activated protein kinase) MAPK signaling pathways. In this study, we examined the effect of RIPK4 on the canonical Smad-mediated TGF-beta 1 signaling pathway by using the immortalized human keratinocyte HaCaT cell line. According to our results, RIPK4 inhibits intracellular Smad-mediated TGF-beta 1 signaling events through suppression of TGF-beta 1-induced Smad2/3 phosphorylation, which is reflected in the upcoming intracellular events including Smad2/3-Smad4 interaction, nuclear localization, and TGF-beta 1-induced gene expression. Moreover, the kinase activity of RIPK4 is required for this process. The in vitro wound-scratch assay demonstrated that RIPK4 suppressed TGF-beta 1-mediated wound healing through blocking TGF-beta 1-induced cell migration. In conclusion, our results showed the antagonistic effect of RIPK4 on TGF-beta 1 signaling in keratinocytes for the first time and have the potential to contribute to the understanding and treatment of skin diseases associated with aberrant TGF-beta 1 signaling.</subfield>
  </datafield>
  <datafield tag="650" ind1="1" ind2="7">
    <subfield code="2">opendefinition.org</subfield>
    <subfield code="a">cc-by</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Karadeniz Tech Univ, Inst Hlth Sci, Dept Med Biol, TR-61080 Trabzon, Turkey</subfield>
    <subfield code="a">Er, Asiye Busra Boz</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Karadeniz Tech Univ, Inst Hlth Sci, Dept Med Biol, TR-61080 Trabzon, Turkey</subfield>
    <subfield code="a">Er, Idris</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Karadeniz Tech Univ, Fac Med, Dept Med Biol, TR-61080 Trabzon, Turkey</subfield>
    <subfield code="a">Toraman, Bayram</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Karadeniz Tech Univ, Fac Med, Dept Med Biol, TR-61080 Trabzon, Turkey</subfield>
    <subfield code="a">Yildiz, Gokhan</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Karadeniz Tech Univ, Fac Med, Dept Med Biol, TR-61080 Trabzon, Turkey</subfield>
    <subfield code="a">Kalay, Ersan</subfield>
  </datafield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="b">article</subfield>
    <subfield code="a">publication</subfield>
  </datafield>
  <datafield tag="542" ind1=" " ind2=" ">
    <subfield code="l">open</subfield>
  </datafield>
  <datafield tag="100" ind1=" " ind2=" ">
    <subfield code="u">Karadeniz Tech Univ, Fac Med, Dept Med Biol, TR-61080 Trabzon, Turkey</subfield>
    <subfield code="a">Dincer, Tuba</subfield>
  </datafield>
  <datafield tag="260" ind1=" " ind2=" ">
    <subfield code="c">2020-01-01</subfield>
  </datafield>
  <controlfield tag="005">20210315074053.0</controlfield>
  <datafield tag="909" ind1="C" ind2="O">
    <subfield code="o">oai:zenodo.org:11493</subfield>
    <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield>
  </datafield>
  <datafield tag="856" ind1="4" ind2=" ">
    <subfield code="z">md5:4ff1e38e6f725119aba45700285a9d44</subfield>
    <subfield code="s">181</subfield>
    <subfield code="u">https://aperta.ulakbim.gov.trrecord/11493/files/bib-bc6bd1a8-a750-4fa5-955f-ef1f3483126e.txt</subfield>
  </datafield>
  <datafield tag="540" ind1=" " ind2=" ">
    <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield>
    <subfield code="a">Creative Commons Attribution</subfield>
  </datafield>
  <datafield tag="024" ind1=" " ind2=" ">
    <subfield code="a">10.1002/cbin.11282</subfield>
    <subfield code="2">doi</subfield>
  </datafield>
</record>