1 Ocak 2020 Dergi makalesi Açık Erişim

Dincer, Tuba; Er, Asiye Busra Boz; Er, Idris; Toraman, Bayram; Yildiz, Gokhan; Kalay, Ersan

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      {
        "affiliation": "Karadeniz Tech Univ, Fac Med, Dept Med Biol, TR-61080 Trabzon, Turkey", 
        "name": "Dincer, Tuba"
      }, 
      {
        "affiliation": "Karadeniz Tech Univ, Inst Hlth Sci, Dept Med Biol, TR-61080 Trabzon, Turkey", 
        "name": "Er, Asiye Busra Boz"
      }, 
      {
        "affiliation": "Karadeniz Tech Univ, Inst Hlth Sci, Dept Med Biol, TR-61080 Trabzon, Turkey", 
        "name": "Er, Idris"
      }, 
      {
        "affiliation": "Karadeniz Tech Univ, Fac Med, Dept Med Biol, TR-61080 Trabzon, Turkey", 
        "name": "Toraman, Bayram"
      }, 
      {
        "affiliation": "Karadeniz Tech Univ, Fac Med, Dept Med Biol, TR-61080 Trabzon, Turkey", 
        "name": "Yildiz, Gokhan"
      }, 
      {
        "affiliation": "Karadeniz Tech Univ, Fac Med, Dept Med Biol, TR-61080 Trabzon, Turkey", 
        "name": "Kalay, Ersan"
      }
    ], 
    "description": "Receptor-interacting serine/threonine kinase 4 (RIPK4) and transforming growth factor-beta 1 (TGF-beta 1) play critical roles in the development and maintenance of the epidermis. A negative correlation between the expression patterns of RIPK4 and TGF-beta signaling during epidermal homeostasis-related events and suppression of RIPK4 expression by TGF-beta 1 in keratinocyte cell lines suggest the presence of a negative regulatory loop between the two factors. So far, RIPK4 has been shown to regulate nuclear factor-kappa B (NF-kappa B), protein kinase C (PKC), wingless-type MMTV integration site family (Wnt), and (mitogen-activated protein kinase) MAPK signaling pathways. In this study, we examined the effect of RIPK4 on the canonical Smad-mediated TGF-beta 1 signaling pathway by using the immortalized human keratinocyte HaCaT cell line. According to our results, RIPK4 inhibits intracellular Smad-mediated TGF-beta 1 signaling events through suppression of TGF-beta 1-induced Smad2/3 phosphorylation, which is reflected in the upcoming intracellular events including Smad2/3-Smad4 interaction, nuclear localization, and TGF-beta 1-induced gene expression. Moreover, the kinase activity of RIPK4 is required for this process. The in vitro wound-scratch assay demonstrated that RIPK4 suppressed TGF-beta 1-mediated wound healing through blocking TGF-beta 1-induced cell migration. In conclusion, our results showed the antagonistic effect of RIPK4 on TGF-beta 1 signaling in keratinocytes for the first time and have the potential to contribute to the understanding and treatment of skin diseases associated with aberrant TGF-beta 1 signaling.", 
    "doi": "10.1002/cbin.11282", 
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    "journal": {
      "issue": "3", 
      "pages": "848-860", 
      "title": "CELL BIOLOGY INTERNATIONAL", 
      "volume": "44"
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      "id": "cc-by"
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    "publication_date": "2020-01-01", 
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    "resource_type": {
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      "title": "Dergi makalesi", 
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    "title": "RIPK4 suppresses the TGF-beta 1 signaling pathway in HaCaT cells"
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