1 Ocak 2020 Dergi makalesi Açık Erişim

Reeder, Sophia M.; Reuschel, Emma L.; Bah, Mamadou A.; Yun, Kun; Tursi, Nicholas J.; Kim, Kevin Y.; Chu, Jacqueline; Zaidi, Faraz, I; Yilmaz, Ilknur; Hart, Robert J.; Perrin, Benjamin; Xu, Ziyang; Humeau, Laurent; Weiner, David B.; Aly, Ahmed S., I

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/10305</identifier>
  <creators>
    <creator>
      <creatorName>Reeder, Sophia M.</creatorName>
      <givenName>Sophia M.</givenName>
      <familyName>Reeder</familyName>
    </creator>
    <creator>
      <creatorName>Reuschel, Emma L.</creatorName>
      <givenName>Emma L.</givenName>
      <familyName>Reuschel</familyName>
      <affiliation>Vaccine Ctr, Wistar Inst, Philadelphia, PA 19104 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Bah, Mamadou A.</creatorName>
      <givenName>Mamadou A.</givenName>
      <familyName>Bah</familyName>
      <affiliation>Vaccine Ctr, Wistar Inst, Philadelphia, PA 19104 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Yun, Kun</creatorName>
      <givenName>Kun</givenName>
      <familyName>Yun</familyName>
    </creator>
    <creator>
      <creatorName>Tursi, Nicholas J.</creatorName>
      <givenName>Nicholas J.</givenName>
      <familyName>Tursi</familyName>
      <affiliation>Vaccine Ctr, Wistar Inst, Philadelphia, PA 19104 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Kim, Kevin Y.</creatorName>
      <givenName>Kevin Y.</givenName>
      <familyName>Kim</familyName>
      <affiliation>Vaccine Ctr, Wistar Inst, Philadelphia, PA 19104 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Chu, Jacqueline</creatorName>
      <givenName>Jacqueline</givenName>
      <familyName>Chu</familyName>
      <affiliation>Vaccine Ctr, Wistar Inst, Philadelphia, PA 19104 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Zaidi, Faraz, I</creatorName>
      <affiliation>Vaccine Ctr, Wistar Inst, Philadelphia, PA 19104 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Yilmaz, Ilknur</creatorName>
      <givenName>Ilknur</givenName>
      <familyName>Yilmaz</familyName>
      <affiliation>Bezmialem Vakif Univ, Beykoz Inst Life Sci &amp; Biotechnol, Istanbul 34820, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Hart, Robert J.</creatorName>
      <givenName>Robert J.</givenName>
      <familyName>Hart</familyName>
      <affiliation>Tulane Univ, Dept Trop Med, New Orleans, LA 70112 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Perrin, Benjamin</creatorName>
      <givenName>Benjamin</givenName>
      <familyName>Perrin</familyName>
      <affiliation>Tulane Univ, Dept Trop Med, New Orleans, LA 70112 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Xu, Ziyang</creatorName>
      <givenName>Ziyang</givenName>
      <familyName>Xu</familyName>
    </creator>
    <creator>
      <creatorName>Humeau, Laurent</creatorName>
      <givenName>Laurent</givenName>
      <familyName>Humeau</familyName>
      <affiliation>Inovio Pharmaceut Inc, Plymouth Meeting, PA 19462 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Weiner, David B.</creatorName>
      <givenName>David B.</givenName>
      <familyName>Weiner</familyName>
      <affiliation>Vaccine Ctr, Wistar Inst, Philadelphia, PA 19104 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Aly, Ahmed S., I</creatorName>
    </creator>
  </creators>
  <titles>
    <title>Synthetic Dna Vaccines Adjuvanted With Pil-33 Drive Liver-Localized T Cells And Provide Protection From Plasmodium Challenge In A Mouse Model</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2020</publicationYear>
  <dates>
    <date dateType="Issued">2020-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/10305</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.3390/vaccines8010021</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">The need for a malaria vaccine is indisputable. A single vaccine for Plasmodium pre-erythrocytic stages targeting the major sporozoite antigen circumsporozoite protein (CSP) has had partial success. Additionally, CD8+ T cells targeting liver-stage (LS) antigens induced by live attenuated sporozoite vaccines were associated with protection in human challenge experiments. To further evaluate protection mediated by LS antigens, we focused on exported pre-erythrocytic proteins (exported protein 1 (EXP1), profilin (PFN), exported protein 2 (EXP2), inhibitor of cysteine proteases (ICP), transmembrane protein 21 (TMP21), and upregulated in infective sporozoites-3 (UIS3)) expressed in all Plasmodium species and designed optimized, synthetic DNA (synDNA) immunogens. SynDNA antigen cocktails were tested with and without the molecular adjuvant plasmid IL-33. Immunized animals developed robust T cell responses including induction of antigen-specific liver-localized CD8+ T cells, which were enhanced by the co-delivery of plasmid IL-33. In total, 100% of mice in adjuvanted groups and 71%-88% in non-adjuvanted groups were protected from blood-stage disease following Plasmodium yoelii sporozoite challenge. This study supports the potential of synDNA LS antigens as vaccine components for malaria parasite infection.</description>
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