1 Ocak 2020 Dergi makalesi Açık Erişim

Dikmen, Miris; Ozturk, Selin Engur; Canturk, Zerrin; Ceylan, Goksu; Karaduman, Ayse Betul; Yamac, Mustafa

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/9669</identifier>
  <creators>
    <creator>
      <creatorName>Dikmen, Miris</creatorName>
      <givenName>Miris</givenName>
      <familyName>Dikmen</familyName>
      <affiliation>Anadolu Univ, Fac Pharm, Dept Pharmacol, TR-26210 Eskisehir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozturk, Selin Engur</creatorName>
      <givenName>Selin Engur</givenName>
      <familyName>Ozturk</familyName>
      <affiliation>Pamukkale Univ, Tavas Vocat Sch Hlth Serv, Denizli, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Canturk, Zerrin</creatorName>
      <givenName>Zerrin</givenName>
      <familyName>Canturk</familyName>
      <affiliation>Anadolu Univ, Fac Pharm, Dept Pharmaceut Microbiol, TR-26210 Eskisehir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ceylan, Goksu</creatorName>
      <givenName>Goksu</givenName>
      <familyName>Ceylan</familyName>
      <affiliation>Gazi Univ, Publ Hlth Res &amp; Applicat Ctr, Cent Immunol Lab, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Karaduman, Ayse Betul</creatorName>
      <givenName>Ayse Betul</givenName>
      <familyName>Karaduman</familyName>
      <affiliation>Duzen Norwest Labs, Kaptanpasa St 2, TR-06700 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Yamac, Mustafa</creatorName>
      <givenName>Mustafa</givenName>
      <familyName>Yamac</familyName>
      <affiliation>Eskisehir Osmangazi Univ, Fac Sci &amp; Letters, Dept Biol, TR-26480 Eskisehir, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Anticancer And Antimetastatic Activity Of Hypomyces Chrysospermus, A Cosmopolitan Parasite In Different Human Cancer Cells</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2020</publicationYear>
  <dates>
    <date dateType="Issued">2020-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/9669</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1007/s11033-020-05468-6</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">The importance of microbial natural compounds in drug research is increasing every year and they are used to prevent or treat a variety of diseases. Hypomyces chrysospermus is a cosmopolitan parasite of many Boletaceae members. Since not much work has been conducted to date, this study is undertaken to explore the anticancer effect, including the antiproliferative and antimetastatic activity of Hypomyces chrysospermus. The aim of this study is to determine the antiproliferative and antimetastatic activity of Hypomyces chrysospermus ethyl acetate extract, having antioxidant activity, against A549, Caco2, MCF-7 human cancer and CCD-19 Lu and CCD 841 CoN healthy human cell lines. Firstly, cytotoxic activity was determined by the WST-1 assay. After cell proliferations and anti-metastatic effects were investigated by a real-time cell analysis system (RTCA-DP) and IC50 concentrations were calculated for each cell line. In addition, the expression levels of Apaf-1, TNF and NF-kB mRNA in cancer cells were investigated with RealTime-PCR. The ethyl acetate extract of Hypomyces chrysospermus presented anticancer activities including antiproliferative and antimetastatic effects. Hypomyces chrysospermus as a source of biologically active metabolites can be used as an important resource in the development of new anticancer effective agents.</description>
  </descriptions>
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