1 Ocak 2004 Dergi makalesi Açık Erişim

Lefevre, C; Bouadjar, B; Karaduman, A; Jobard, F; Saker, S; Ozguc, M; Lathrop, M; Prud'homme, JF; Fischer, J

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{
  "@context": "https://schema.org/", 
  "@id": 94701, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "name": "Lefevre, C"
    }, 
    {
      "@type": "Person", 
      "name": "Bouadjar, B"
    }, 
    {
      "@type": "Person", 
      "name": "Karaduman, A"
    }, 
    {
      "@type": "Person", 
      "name": "Jobard, F"
    }, 
    {
      "@type": "Person", 
      "name": "Saker, S"
    }, 
    {
      "@type": "Person", 
      "name": "Ozguc, M"
    }, 
    {
      "@type": "Person", 
      "name": "Lathrop, M"
    }, 
    {
      "@type": "Person", 
      "name": "Prud'homme, JF"
    }, 
    {
      "@type": "Person", 
      "name": "Fischer, J"
    }
  ], 
  "datePublished": "2004-01-01", 
  "description": "We report the genomic localization by homozygosity mapping and the identification of a gene for a new form of non-syndromic autosomal recessive congenital ichthyosis. The phenotype usually presents as non-bullous congenital ichthyosiform erythroderma with fine whitish scaling on an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs. A few patients presented a more generalized lamellar ichthyosis. Palmoplantar keratoderma was present in all cases, whereas only 60% of the patients were born as collodion babies. Six homozygous mutations including one nonsense and five missense mutations were identified in a new gene, ichthyin, on chromosome 5q33 in 23 patients from 14 consanguineous families from Algeria, Colombia, Syria and Turkey. Ichthyin encodes a protein with several transmembrane domains which belongs to a new family of proteins of unknown function localized in the plasma membrane (PFAM: DUF803), with homologies to both transporters and G-protein coupled receptors. This family includes NIPA1, in which a mutation was recently described in a dominant form of spastic paraplegia (SPG6). We propose that ichthyin and NIPA1 are membrane receptors for ligands (trioxilins A3 and B3) from the hepoxilin pathway.", 
  "headline": "Mutations in ichthyin a new gene on chromosome 5q33 in a new form of autosomal recessive congenital ichthyosis", 
  "identifier": 94701, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Mutations in ichthyin a new gene on chromosome 5q33 in a new form of autosomal recessive congenital ichthyosis", 
  "url": "https://aperta.ulakbim.gov.tr/record/94701"
}