1 Ocak 2018 Dergi makalesi Açık Erişim

Sezer, Umran Aydemir; Ozturk, Kevser; Aru, Basak; Demirel, Gulderen Yanikkaya; Sezer, Serdar

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    <subfield code="a">A design achieved by coaxial electrospinning of polysulfone and sulfonated polysulfone as a core-shell structure to optimize mechanical strength and hemocompatibility</subfield>
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    <subfield code="a">Hemocompatibility is an essential quality for blood contacting materials in clinical applications. Blood contacting biomaterials should not initiate blood coagulation while performing their functions. There has been a long-standing tendency to use heparinized or heparin-like structures in the materials for blood contacting sites. However, such structures might lead to limitations in mechanical properties due to the breakage of bonds on the backbone or phase separation in case of blending. Moreover, the methods including plasma and grafting synthesis are restricted due to their high costs and difficulties in industrial applications. In this study, we investigated a core-shell electrospun structure having polysulfone in the core part and sulfonated polysulfone in the shell part. We proved that this combination is more hemocompatible than polysulfone itself and offers a more stable mechanical structure than the sulfonated polysulfone itself does. Chemical and physical characterizations indicated that the sulfonated polysulfone covered the core structure of the polysulfone properly. We conducted in vitro studies in order to determine the blood compatibility and cytotoxicity of the core-shell material. The results indicated that the membranes were hemocompatible and mechanically strong; which makes it possible to use them in blood contacting applications.</subfield>
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