1 Ocak 2013 Dergi makalesi Açık Erişim

Hatipoglu, Ibrahim; Sogut, Ibrahim; Ercan, Duygu; Aksu, Soner; Sivas, Hulya; Basalp, Aynur

MARC21 XML

<?xml version='1.0' encoding='UTF-8'?>
<record xmlns="http://www.loc.gov/MARC21/slim">
  <leader>00000nam##2200000uu#4500</leader>
  <controlfield tag="001">91797</controlfield>
  <datafield tag="540" ind1=" " ind2=" ">
    <subfield code="a">Creative Commons Attribution</subfield>
    <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="4">
    <subfield code="v">37</subfield>
    <subfield code="p">TURKISH JOURNAL OF BIOLOGY</subfield>
    <subfield code="n">4</subfield>
    <subfield code="c">457-463</subfield>
  </datafield>
  <controlfield tag="005">20210316122610.0</controlfield>
  <datafield tag="520" ind1=" " ind2=" ">
    <subfield code="a">Dendritic cell (DC) vaccines are a promising and potent therapeutic tool for chronic diseases, autoimmune diseases, and cancer because of the unique ability of DCs to stimulate T cells. The challenge of DC vaccines is to find an effective form for antigen presentation. Although pure antigens, antigen complexes, plasmids, and mRNA have been used in different studies, no proper application to overcome this problem has been found yet. In this study, we investigated the eligibility of a commercial hepatitis B virus (HBV) vaccine or a vaccine-monoclonal antibody complex for antigen loading of DCs for a therapeutic purpose. DCs were derived from the bone marrow of transgenic hepatitis B (HBV-tg) mice using a granulocyte macrophage-colony stimulating factor and interleukin-4, and then loaded with a commercial HBV vaccine (containing hepatitis B virus surface antigens and aluminum hydroxide adjuvant) or a vaccine-antibody complex. HBV-tg mice were immunized with the vaccine and vaccine-antibody loaded DCs. Optimum HBV vaccine concentration and loading time were determined by 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium (WST-1) methods. Therapeutic effects of vaccine-antibody loaded DCs were determined by the evaluation of antibody response and hepatitis B surface expression levels in HBV-tg mice. Our results showed that commercial HBV vaccine loaded DCs induced humoral response in HBV-tg mice but had no effect on cellular immunity.</subfield>
  </datafield>
  <datafield tag="245" ind1=" " ind2=" ">
    <subfield code="a">Stimulation of dendritic cells with vaccine and vaccine-antibody complex and effect on immune response</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="O">
    <subfield code="p">user-tubitak-adresli-yayinlar</subfield>
    <subfield code="o">oai:zenodo.org:91797</subfield>
  </datafield>
  <datafield tag="542" ind1=" " ind2=" ">
    <subfield code="l">open</subfield>
  </datafield>
  <datafield tag="100" ind1=" " ind2=" ">
    <subfield code="a">Hatipoglu, Ibrahim</subfield>
  </datafield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">user-tubitak-adresli-yayinlar</subfield>
  </datafield>
  <datafield tag="856" ind1="4" ind2=" ">
    <subfield code="z">md5:96a856e83dac765ef18db5bf35e7895a</subfield>
    <subfield code="s">91850</subfield>
    <subfield code="u">https://aperta.ulakbim.gov.trrecord/91797/files/10-3906-biy-1209-36.pdf</subfield>
  </datafield>
  <datafield tag="024" ind1=" " ind2=" ">
    <subfield code="2">doi</subfield>
    <subfield code="a">10.3906/biy-1209-36</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Istanbul Bilim Univ, Vocat Sch Hlth Serv, Istanbul, Turkey</subfield>
    <subfield code="a">Sogut, Ibrahim</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">TUBITAK Marmara Res Ctr, Genet Engn &amp; Biotechnol Inst, Gebze, Kocaeli, Turkey</subfield>
    <subfield code="a">Ercan, Duygu</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">TUBITAK Marmara Res Ctr, Genet Engn &amp; Biotechnol Inst, Gebze, Kocaeli, Turkey</subfield>
    <subfield code="a">Aksu, Soner</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Anadolu Univ, Fac Sci, Dept Biol, Eskisehir, Turkey</subfield>
    <subfield code="a">Sivas, Hulya</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">TUBITAK Marmara Res Ctr, Genet Engn &amp; Biotechnol Inst, Gebze, Kocaeli, Turkey</subfield>
    <subfield code="a">Basalp, Aynur</subfield>
  </datafield>
  <datafield tag="650" ind1="1" ind2="7">
    <subfield code="a">cc-by</subfield>
    <subfield code="2">opendefinition.org</subfield>
  </datafield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">publication</subfield>
    <subfield code="b">article</subfield>
  </datafield>
  <datafield tag="260" ind1=" " ind2=" ">
    <subfield code="c">2013-01-01</subfield>
  </datafield>
</record>