1 Ocak 2019 Dergi makalesi Açık Erişim

Heydari, Hajar; Koc, Asli; Simsek, Duygu; Gozcelioglu, Bulent; Altanlar, Nurten; Konuklugil, Belma

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/90675</identifier>
  <creators>
    <creator>
      <creatorName>Heydari, Hajar</creatorName>
      <givenName>Hajar</givenName>
      <familyName>Heydari</familyName>
      <affiliation>Ankara Univ, Pharmacognosy Dept, TR-06100 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Koc, Asli</creatorName>
      <givenName>Asli</givenName>
      <familyName>Koc</familyName>
      <affiliation>Ankara Univ, Biochem Dept, TR-06100 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Simsek, Duygu</creatorName>
      <givenName>Duygu</givenName>
      <familyName>Simsek</familyName>
      <affiliation>Ankara Univ, Pharmaceut Microbiol Dept, TR-06100 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Gozcelioglu, Bulent</creatorName>
      <givenName>Bulent</givenName>
      <familyName>Gozcelioglu</familyName>
      <affiliation>Sci &amp; Technol Res Council Turkey TUBITAK, TR-06420 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Altanlar, Nurten</creatorName>
      <givenName>Nurten</givenName>
      <familyName>Altanlar</familyName>
      <affiliation>Ankara Univ, Pharmaceut Microbiol Dept, TR-06100 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Konuklugil, Belma</creatorName>
      <givenName>Belma</givenName>
      <familyName>Konuklugil</familyName>
      <affiliation>Ankara Univ, Pharmacognosy Dept, TR-06100 Ankara, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Isolation, Identification And Bioactivity Screening Of Turkish Marine-Derived Fungi</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2019</publicationYear>
  <dates>
    <date dateType="Issued">2019-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/90675</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.31925/farmacia.2019.5.5</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Marine-derived fungi are considered as a promising source for discovering new secondary metabolites with pharmaceutical potential. In this study, 18 marine-derived fungi were isolated and identified from marine invertebrates and investigated with regard to their antioxidant, antimicrobial and cytotoxic activities. DPPH, SO, NO and ABTS assays were used for monitoring free radical scavenging activity, and MTT assay was used for cytotoxic activity. For antimicrobial activity determination minimum inhibitory concentration was calculated. As a result, six Penicillium, five Aspergillus, one Alternaria, Cladosporium, Malassezia, Mycosphaerella, Sporobolomyces, Talaromyces and Trichoderma species were isolated from the marine invertebrate. Some of these fungal extracts such as Aspergillus chevalieri has shown high antioxidant and antimicrobial activities, further Aspergillus awamori, Aspergillus niger and Penicillium brevicompactum have shown significant cytotoxic activity against HCT-116 cells. This was the first study about habitant of marine-derived fungi of Turkey's coasts and their antioxidant, antimicrobial and cytotoxicity activities. Besides, it is also the first report about the antioxidant and cytotoxicity activities of C. funiculosum, A. awamori and P. crustosum. Antioxidant and antimicrobial activities of P. rubens were reported for the first time in this study.</description>
  </descriptions>
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