1 Ocak 2021 Dergi makalesi Açık Erişim

Ozkose, Umut Ugur; Gulyuz, Sevgi; Parlak Khalily, Melek; Ozcubukcu, Salih; Bozkir, Asuman; Tasdelen, Mehmet Atilla; Alpturk, Onur; Yilmaz, Ozgur

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{
  "@context": "https://schema.org/", 
  "@id": 89109, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "name": "Ozkose, Umut Ugur"
    }, 
    {
      "@type": "Person", 
      "name": "Gulyuz, Sevgi"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Yozgat Bozok Univ, Fac Sci & Letters, Dept Chem, Yozgat, Turkey", 
      "name": "Parlak Khalily, Melek"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Middle East Tech Univ, Dept Chem, Fac Sci, Ankara, Turkey", 
      "name": "Ozcubukcu, Salih"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ankara Univ, Dept Pharmaceut Technol, Fac Pharm, Ankara, Turkey", 
      "name": "Bozkir, Asuman"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Yalova Univ, Dept Polymer Engn, Fac Engn, Yalova, Turkey", 
      "name": "Tasdelen, Mehmet Atilla"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Istanbul Tech Univ, Fac Sci & Letters, Dept Chem, TR-34469 Istanbul, Turkey", 
      "name": "Alpturk, Onur"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Marmara Res Ctr, Mat Inst, Kocaeli, Turkey", 
      "name": "Yilmaz, Ozgur"
    }
  ], 
  "datePublished": "2021-01-01", 
  "description": "To optimize the therapeutic effect of pharmaceutical agents, drug delivery systems tailored from FDA-approved polymers like poly(L-lactide) (PLA) is an effective strategy. Because of their hydrophobic character, these systems greatly suffer from reduced circulation time thus, amphiphilic block copolymers became favorable to overcome this limitation. Of them, poly(oxazoline)-b-poly(L-lactide) are of choice as poly(oxazoline) (PEtOx) is compatible, biodegradable, while exhibiting minimum cytotoxicity. To tailor selective drug targeting drug delivery systems, whereby their selectivity for tumor tissues is maximized, these polymers should be decorated with so-called tumor-homing agents, such as antibodies, peptides and so forth. To this respect, we designed a new block copolymer, allyl-poly(2-ethyl-2-oxazoline)-b-poly(L-lactide) allyl-(PEtOx-b-PLA) and its subsequent conjugation to tumor-homing peptides, peptide-18, and peptide-563 at the terminal position. In this manuscript, we report our synthetic route to obtain this building block and its conjugation to tumor-homing agents.", 
  "headline": "The synthesis of peptide-conjugated poly(2-ethyl-2-oxazoline)-b-poly(L-lactide) (PEtOx-b-PLA) polymeric systems through the combination of controlled polymerization techniques and click reactions", 
  "identifier": 89109, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "The synthesis of peptide-conjugated poly(2-ethyl-2-oxazoline)-b-poly(L-lactide) (PEtOx-b-PLA) polymeric systems through the combination of controlled polymerization techniques and click reactions", 
  "url": "https://aperta.ulakbim.gov.tr/record/89109"
}