1 Ocak 2020 Dergi makalesi Açık Erişim

Dost, Turhan

Citation Style Language JSON

{
  "DOI": "10.1007/s43440-019-00046-5", 
  "abstract": "Objective The effects of prasugrel, a third-generation thienopyridine, on myocardial infarction, and ischemia-induced ventricular arrhythmias was evaluated in open-chest anesthetized rats. The role of protein kinase C and phosphoinositide 3-kinase pathways in these effects was also examined. Methods The effect of P2Y(12) receptor inhibition by prasugrel (3-10 mg/kg, po) on infarct size after 30-min coronary artery occlusion and 120-min reperfusion or on arrhythmias after 7-min coronary occlusion and 7-min reperfusion was evaluated. Results In the control group, 31.25 +/- 3.01% of the risk zone infarcted. At both prasugrel doses, infarct size was significantly smaller than that in the control group: 5.03 +/- 0.81% for 3 mg/kg (p < 0.0001), and 8.78 +/- 2.04% for 10 mg/kg (p < 0.0001). The protein kinase C antagonist chelerythrine abolished the anti-infarct effect of prasugrel at 24.77 +/- 1.73% as did the phosphoinositide 3-kinase antagonist wortmannin abolished the anti-infarct effect of prasugrel at 27.45 +/- 2.74%. Ten mg/kg prasugrel reduced the duration of VT (p = 0.0152 vs control), and wortmannin, but not chelerythrine, reversed the effect of prasugrel on arrhythmias (p = 0.0295). Conclusion The selective P2Y(12) inhibitor prasugrel provides effective protection against myocardial infarction and ischemia-induced ventricular arrhythmias in rats. As in ischemic postconditioning, protein kinase C and phosphoinositide 3-kinase signaling pathways play a role in this protection. Graphic abstract", 
  "author": [
    {
      "family": "Dost", 
      "given": " Turhan"
    }
  ], 
  "container_title": "PHARMACOLOGICAL REPORTS", 
  "id": "8861", 
  "issue": "3", 
  "issued": {
    "date-parts": [
      [
        2020, 
        1, 
        1
      ]
    ]
  }, 
  "page": "672-679", 
  "title": "Cardioprotective properties of the platelet P2Y(12) receptor inhibitor prasugrel on cardiac ischemia/reperfusion injury", 
  "type": "article-journal", 
  "volume": "72"
}