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Enginar, H.; Unak, P.; Muftuler, F. Z. Biber; Lambrecht, F. Y.; Medine, E. I.; Yolcular, S.; Kilcar, A. Yurt; Seyitoglu, B.; Bulduk, I.
<?xml version='1.0' encoding='utf-8'?> <resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns="http://datacite.org/schema/kernel-4" xsi:schemaLocation="http://datacite.org/schema/kernel-4 http://schema.datacite.org/meta/kernel-4.1/metadata.xsd"> <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/87589</identifier> <creators> <creator> <creatorName>Enginar, H.</creatorName> <givenName>H.</givenName> <familyName>Enginar</familyName> <affiliation>Afyon Kocatepe Univ, Dept Chem, Afyon, Turkey</affiliation> </creator> <creator> <creatorName>Unak, P.</creatorName> <givenName>P.</givenName> <familyName>Unak</familyName> <affiliation>Ege Univ, Inst Nucl Sci, Izmir, Turkey</affiliation> </creator> <creator> <creatorName>Muftuler, F. Z. Biber</creatorName> <givenName>F. Z. Biber</givenName> <familyName>Muftuler</familyName> <affiliation>Ege Univ, Inst Nucl Sci, Izmir, Turkey</affiliation> </creator> <creator> <creatorName>Lambrecht, F. Y.</creatorName> <givenName>F. Y.</givenName> <familyName>Lambrecht</familyName> <affiliation>Ege Univ, Inst Nucl Sci, Izmir, Turkey</affiliation> </creator> <creator> <creatorName>Medine, E. I.</creatorName> <givenName>E. I.</givenName> <familyName>Medine</familyName> <affiliation>Ege Univ, Inst Nucl Sci, Izmir, Turkey</affiliation> </creator> <creator> <creatorName>Yolcular, S.</creatorName> <givenName>S.</givenName> <familyName>Yolcular</familyName> <affiliation>Ege Univ, Inst Nucl Sci, Izmir, Turkey</affiliation> </creator> <creator> <creatorName>Kilcar, A. Yurt</creatorName> <givenName>A. Yurt</givenName> <familyName>Kilcar</familyName> <affiliation>Ege Univ, Inst Nucl Sci, Izmir, Turkey</affiliation> </creator> <creator> <creatorName>Seyitoglu, B.</creatorName> <givenName>B.</givenName> <familyName>Seyitoglu</familyName> <affiliation>Ege Univ, Inst Nucl Sci, Izmir, Turkey</affiliation> </creator> <creator> <creatorName>Bulduk, I.</creatorName> <givenName>I.</givenName> <familyName>Bulduk</familyName> <affiliation>Bolvadin Alkaloid Factory, Afyon, Turkey</affiliation> </creator> </creators> <titles> <title>Synthesis, Radiolabeling And Biodistribution Of Morphine Glucuronide (Mor-Glu)</title> </titles> <publisher>Aperta</publisher> <publicationYear>2012</publicationYear> <dates> <date dateType="Issued">2012-01-01</date> </dates> <resourceType resourceTypeGeneral="Text">Journal article</resourceType> <alternateIdentifiers> <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/87589</alternateIdentifier> </alternateIdentifiers> <relatedIdentifiers> <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1007/s10967-011-1412-4</relatedIdentifier> </relatedIdentifiers> <rightsList> <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights> <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights> </rightsList> <descriptions> <description descriptionType="Abstract">The aim of this study was to synthesize a glucuronide conjugated morphine derivative which could be labeled with I-131, as a radiopharmaceutical, and to investigate its radiopharmaceutical potential using biodistribution studies in male Albino Wistar rats. Morphine was extracted from dry capsules of the opium poppy (Papaver somniferum L.). It was conjugated with UDP-glucuronic acid by using UDP-glucuronyl transferase (UDPGT) enzyme rich microsomes, purified by high performance liquid chromatography (HPLC) and characterized by nuclear magnetic resonance (NMR), infrared (IR) spectroscopy and liquid chromatography mass spectroscopy (LC-MS/MS). Normal and receptor blockage biodistribution studies were performed in male Albino Wistar rats. The results of the tissue distribution studies showed that I-131 labeled morphine glucuronide (I-131-mor-glu) uptake in the small intestine, large intestine and urinary bladder was higher than in the other tissues of the rats in the blocked receptor and unblocked receptor. A greater uptake of the radio labeled substance was observed in the hypothalamus and mid brain than in the other branches of the rats' brains.</description> </descriptions> </resource>
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