1 Ocak 2012 Dergi makalesi Açık Erişim

Cevik, Safak Isil; Keskin, Nazli; Belkaya, Serkan; Ozlu, Meral Ilcim; Deniz, Emre; Tazebay, Uygar Halis; Erman, Batu

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/86037</identifier>
  <creators>
    <creator>
      <creatorName>Cevik, Safak Isil</creatorName>
      <givenName>Safak Isil</givenName>
      <familyName>Cevik</familyName>
    </creator>
    <creator>
      <creatorName>Keskin, Nazli</creatorName>
      <givenName>Nazli</givenName>
      <familyName>Keskin</familyName>
    </creator>
    <creator>
      <creatorName>Belkaya, Serkan</creatorName>
      <givenName>Serkan</givenName>
      <familyName>Belkaya</familyName>
      <affiliation>Sabanci Univ, Fac Engn &amp; Nat Sci, Biol Sci &amp; Bioengn Program, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozlu, Meral Ilcim</creatorName>
      <givenName>Meral Ilcim</givenName>
      <familyName>Ozlu</familyName>
      <affiliation>Sabanci Univ, Fac Engn &amp; Nat Sci, Biol Sci &amp; Bioengn Program, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Deniz, Emre</creatorName>
      <givenName>Emre</givenName>
      <familyName>Deniz</familyName>
    </creator>
    <creator>
      <creatorName>Tazebay, Uygar Halis</creatorName>
      <givenName>Uygar Halis</givenName>
      <familyName>Tazebay</familyName>
      <affiliation>Bilkent Univ, Dept Mol Biol &amp; Genet, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Erman, Batu</creatorName>
      <givenName>Batu</givenName>
      <familyName>Erman</familyName>
    </creator>
  </creators>
  <titles>
    <title>Cd81 Interacts With The T Cell Receptor To Suppress Signaling</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2012</publicationYear>
  <dates>
    <date dateType="Issued">2012-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/86037</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1371/journal.pone.0050396</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">CD81 (TAPA-1) is a ubiquitously expressed tetraspanin protein identified as a component of the B lymphocyte receptor (BCR) and as a receptor for the Hepatitis C Virus. In an effort to identify trans-membrane proteins that interact with the T-cell antigen receptor (TCR), we performed a membrane yeast two hybrid screen and identified CD81 as an interactor of the CD3delta subunit of the TCR. We found that in the absence of CD81, in thymocytes from knockout mice, TCR engagement resulted in stronger signals. These results were recapitulated in T cell lines that express low levels of CD81 through shRNA mediated silencing. Increased signaling did not result from alterations in the levels of TCR on the surface of T lymphocytes. Although CD81 is not essential for normal T lymphocyte development, it plays an important role in regulating TCR and possibly pre-TCR signal transduction by controlling the strength of signaling. CD81 dependent alterations in thymocyte signaling are evident in increased CD5 expression on CD81 deficient double positive (DP) thymocytes. We conclude that CD81 interacts with the T cell receptor to suppress signaling.</description>
  </descriptions>
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