1 Ocak 2012 Dergi makalesi Açık Erişim

Xu, Feng; Inci, Fatih; Mullick, Omer; Gurkan, Umut Atakan; Sung, Yuree; Kavaz, Doga; Li, Baoqiang; Denkbas, Emir Baki; Demirci, Utkan

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/85163</identifier>
  <creators>
    <creator>
      <creatorName>Xu, Feng</creatorName>
      <givenName>Feng</givenName>
      <familyName>Xu</familyName>
      <affiliation>Harvard Univ, Sch Med, Brigham &amp; Womens Hosp, Ctr Biomed Engn,Dept Med,Demirci Bioacoust MEMS M, Boston, MA 02139 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Inci, Fatih</creatorName>
      <givenName>Fatih</givenName>
      <familyName>Inci</familyName>
      <affiliation>Harvard Univ, Sch Med, Brigham &amp; Womens Hosp, Ctr Biomed Engn,Dept Med,Demirci Bioacoust MEMS M, Boston, MA 02139 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Mullick, Omer</creatorName>
      <givenName>Omer</givenName>
      <familyName>Mullick</familyName>
      <affiliation>Harvard Univ, Sch Med, Brigham &amp; Womens Hosp, Ctr Biomed Engn,Dept Med,Demirci Bioacoust MEMS M, Boston, MA 02139 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Gurkan, Umut Atakan</creatorName>
      <givenName>Umut Atakan</givenName>
      <familyName>Gurkan</familyName>
      <affiliation>Harvard Univ, Sch Med, Brigham &amp; Womens Hosp, Ctr Biomed Engn,Dept Med,Demirci Bioacoust MEMS M, Boston, MA 02139 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Sung, Yuree</creatorName>
      <givenName>Yuree</givenName>
      <familyName>Sung</familyName>
      <affiliation>Harvard Univ, Sch Med, Brigham &amp; Womens Hosp, Ctr Biomed Engn,Dept Med,Demirci Bioacoust MEMS M, Boston, MA 02139 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Kavaz, Doga</creatorName>
      <givenName>Doga</givenName>
      <familyName>Kavaz</familyName>
      <affiliation>Harvard Univ, Sch Med, Brigham &amp; Womens Hosp, Ctr Biomed Engn,Dept Med,Demirci Bioacoust MEMS M, Boston, MA 02139 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Li, Baoqiang</creatorName>
      <givenName>Baoqiang</givenName>
      <familyName>Li</familyName>
      <affiliation>Harvard Univ, Sch Med, Brigham &amp; Womens Hosp, Ctr Biomed Engn,Dept Med,Demirci Bioacoust MEMS M, Boston, MA 02139 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Denkbas, Emir Baki</creatorName>
      <givenName>Emir Baki</givenName>
      <familyName>Denkbas</familyName>
      <affiliation>Hacettepe Univ, Inst Grad Studies Sci &amp; Engn, Nanotechnol &amp; Nanomed Div, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Demirci, Utkan</creatorName>
      <givenName>Utkan</givenName>
      <familyName>Demirci</familyName>
    </creator>
  </creators>
  <titles>
    <title>Release Of Magnetic Nanoparticles From Cell-Encapsulating Biodegradable Nanobiomaterials</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2012</publicationYear>
  <dates>
    <date dateType="Issued">2012-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/85163</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1021/nn300902w</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">The future of tissue engineering requires development of intelligent biomaterials using nanopartides. Magnetic nanopartides (MNPs) have several applications in biology and medicine; one example is Food and Drug Administration (FDA)-approved contrast agents in magnetic resonance imaging. Recently, MNPs have been encapsulated within cell-encapsulating hydrogels to create novel nanobiomaterials (i.e., M-gels), which can be manipulated and assembled in magnetic fields. The M-gels can be used as building blocks for bottom-up tissue engineering to create 3D tissue constructs. For tissue engineering applications of M-gels, it is essential to study the release of encapsulated MNPs from the hydrogel polymer network and the effect of MNPs on hydrogel properties, including mechanical characteristics, porosity, swelling behavior, and cellular response (e.g., viability, growth). Therefore, we evaluated the release of MNPs from photocrosslinkable gelatin methacrylate hydrogels as the polymer network undergoes biodegradation using inductively coupled plasma atomic emission spectroscopy. MNP release correlated linearly with hydrogel biodegradation rate with correlation factors (Pearson product moment correlation coefficient) of 0.96 +/- 0.03 and 0.99 +/- 0.01 for MNP concentrations of 1% and 5%, respectively. We also evaluated the effect of MNPs on hydrogel mechanical properties, porosity, and swelling behavior, as well as cell viability and growth in MNP-encapsulating hydrogels. Fibroblasts encapsulated with MNPs in hydrogels remained viable (&amp;gt;80% at t = 144 h) and formed microtissue constructs in culture (t = 144 h). These results indicated that MNP-encapsulating hydrogels show promise as intelligent nanobiomaterials, with great potential to impact broad areas of bioengineering, including tissue engineering, regenerative medicine, and pharmaceutical applications.</description>
  </descriptions>
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