1 Ocak 2012 Dergi makalesi Açık Erişim

Kocabay, Ozge; Emregul, Emel; Aras, Sumer; Emregul, Kaan Cebesoy

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/84561</identifier>
  <creators>
    <creator>
      <creatorName>Kocabay, Ozge</creatorName>
      <givenName>Ozge</givenName>
      <familyName>Kocabay</familyName>
      <affiliation>Ankara Univ, Dept Chem, Fac Sci, TR-06100 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Emregul, Emel</creatorName>
      <givenName>Emel</givenName>
      <familyName>Emregul</familyName>
      <affiliation>Ankara Univ, Dept Chem, Fac Sci, TR-06100 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Aras, Sumer</creatorName>
      <givenName>Sumer</givenName>
      <familyName>Aras</familyName>
      <affiliation>Ankara Univ, Biotechnol Sect, Fac Sci, Dept Biol, TR-06100 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Emregul, Kaan Cebesoy</creatorName>
      <givenName>Kaan Cebesoy</givenName>
      <familyName>Emregul</familyName>
      <affiliation>Ankara Univ, Dept Chem, Fac Sci, TR-06100 Ankara, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Carboxymethylcellulose-Gelatin-Superoxidase Dismutase Electrode For Amperometric Superoxide Radical Sensing</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2012</publicationYear>
  <dates>
    <date dateType="Issued">2012-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/84561</alternateIdentifier>
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  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1007/s00449-011-0677-x</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">A novel, highly sensitive superoxide dismutase biosensor for the direct and simultaneous determination of superoxide radicals was developed by immobilization of superoxide dismutase within carboxymethylcellulose-gelatin on a Pt electrode surface. The parameters affecting the performance of the biosensor were investigated. The response of the CMC-G-SOD biosensor was proportional to O (2) (center dot-) concentration and the detection limit was 1.25 x 10(-3) mM with a correlation coefficient of 0.9994. The developed biosensor exhibited high analytical performance with wider linear range, high sensitivity and low response time. The biosensor retained 89.8% of its sensitivity after use for 80 days. The support system enhanced the immobilization of superoxide dismutase and promoted the electron transfer of superoxide dismutase minimizing its fouling effect. The biosensor was quite effective not only in detecting O (2) (center dot-) , but also in determining the antioxidant properties of acetylsalicylic acid-based drugs and the anti-radical activity of healthy and cancerous human brain tissues.</description>
  </descriptions>
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