1 Ocak 2021 Dergi makalesi Açık Erişim

Unal, Semra; Arslan, Sema; Yilmaz, Betul Karademir; Oktar, Faik Nuzhet; Sengil, Ahmet Zeki; Gunduz, Oguzhan

Citation Style Language JSON

{
  "DOI": "10.1007/s10570-020-03528-5", 
  "abstract": "Three-dimensional (3D) in vitro cell culture models have recently gained increasing interest in predicting the response of anticancer drugs. In this study first, we tried to obtain a novel hyaluronic acid (HA)/gelatin (Gel) modified bacterial cellulose (BC) composite scaffolds by in situ fermentation method. Morphological and chemical structures, wettability, and thermal stability of scaffolds were evaluated. In particular, the human glioblastoma (GBM) cancer cell line (U251) was seeded into BC/HA/Gel scaffolds to evaluate their potential as in vitro 3D cancer cell culture. MTT proliferation assay, scanning electron microscopy, and confocal microscopy were utilised to determine cell proliferation, morphology and adhesion. The results suggest that our hyaluronic acid and gelatin modified bacterial cellulose scaffold is promising to be used as in vitro 3D culture of GBM cells and may be used to predict treatment response or reactions of new therapeutics.", 
  "author": [
    {
      "family": "Unal", 
      "given": " Semra"
    }, 
    {
      "family": "Arslan", 
      "given": " Sema"
    }, 
    {
      "family": "Yilmaz", 
      "given": " Betul Karademir"
    }, 
    {
      "family": "Oktar", 
      "given": " Faik Nuzhet"
    }, 
    {
      "family": "Sengil", 
      "given": " Ahmet Zeki"
    }, 
    {
      "family": "Gunduz", 
      "given": " Oguzhan"
    }
  ], 
  "container_title": "CELLULOSE", 
  "id": "8287", 
  "issue": "1", 
  "issued": {
    "date-parts": [
      [
        2021, 
        1, 
        1
      ]
    ]
  }, 
  "page": "117-132", 
  "title": "Production and characterization of bacterial cellulose scaffold and its modification with hyaluronic acid and gelatin for glioblastoma cell culture", 
  "type": "article-journal", 
  "volume": "28"
}