1 Ocak 2015 Dergi makalesi Açık Erişim

Fidan, Kerem; Kavaklioglu, Gulnihal; Ebrahimi, Ayyub; Ozlu, Can; Ay, Nur Zeynep; Ruacan, Arzu; Gul, Ahmet; Onder, Tamer T.

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/82451</identifier>
  <creators>
    <creator>
      <creatorName>Fidan, Kerem</creatorName>
      <givenName>Kerem</givenName>
      <familyName>Fidan</familyName>
      <affiliation>Koc Univ, Sch Med, TR-34450 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kavaklioglu, Gulnihal</creatorName>
      <givenName>Gulnihal</givenName>
      <familyName>Kavaklioglu</familyName>
      <affiliation>Koc Univ, Sch Med, TR-34450 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ebrahimi, Ayyub</creatorName>
      <givenName>Ayyub</givenName>
      <familyName>Ebrahimi</familyName>
      <affiliation>Koc Univ, Sch Med, TR-34450 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozlu, Can</creatorName>
      <givenName>Can</givenName>
      <familyName>Ozlu</familyName>
      <affiliation>Koc Univ, Sch Med, TR-34450 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ay, Nur Zeynep</creatorName>
      <givenName>Nur Zeynep</givenName>
      <familyName>Ay</familyName>
      <affiliation>Koc Univ, Sch Med, TR-34450 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ruacan, Arzu</creatorName>
      <givenName>Arzu</givenName>
      <familyName>Ruacan</familyName>
      <affiliation>Koc Univ, Sch Med, TR-34450 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Gul, Ahmet</creatorName>
      <givenName>Ahmet</givenName>
      <familyName>Gul</familyName>
      <affiliation>Istanbul Univ, Fac Med, TR-34093 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Onder, Tamer T.</creatorName>
      <givenName>Tamer T.</givenName>
      <familyName>Onder</familyName>
      <affiliation>Koc Univ, Sch Med, TR-34450 Istanbul, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Generation Of Integration-Free Induced Pluripotent Stem Cells From A Patient With Familial Mediterranean Fever (Fmf)</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2015</publicationYear>
  <dates>
    <date dateType="Issued">2015-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/82451</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.scr.2015.10.018</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Fibroblasts from a Familial Mediterranean Fever (FMF) patient were reprogrammed with episomal vectors by using the Neon Transfection System for the generation of integration-free induced pluripotent stem cells (iPSCs). The resulting iPSC line was characterized to determine the expression of pluripotency markers, proper differentiation into three germ layers, the presence of normal chromosomal structures as well as the lack of genomic integration. A homozygous missense mutation in the MEFV gene (p.Met694Val), which lead to typical FMF phenotype, was shown to be present in the generated iPSC line. (C) 2015 The Authors. Published by Elsevier B.V.</description>
  </descriptions>
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