1 Ocak 2015 Dergi makalesi Açık Erişim

Gould, Neal S.; Evans, Perry; Martinez-Acedo, Pablo; Marino, Stefano M.; Gladyshev, Vadim N.; Carroll, Kate S.; Ischiropoulos, Harry

JSON

{
  "conceptrecid": "82210", 
  "created": "2021-03-16T05:58:06.427095+00:00", 
  "doi": "10.1016/j.chembiol.2015.06.010", 
  "files": [
    {
      "bucket": "433eeee7-fbff-46bc-8daf-d58cde73922a", 
      "checksum": "md5:3854122f2d6ebd6ef3a7efab2436ee8b", 
      "key": "bib-0d2cd9fe-b80f-41f1-8f11-06f50699ad88.txt", 
      "links": {
        "self": "https://aperta.ulakbim.gov.tr/api/files/433eeee7-fbff-46bc-8daf-d58cde73922a/bib-0d2cd9fe-b80f-41f1-8f11-06f50699ad88.txt"
      }, 
      "size": 281, 
      "type": "txt"
    }
  ], 
  "id": 82211, 
  "links": {
    "badge": "https://aperta.ulakbim.gov.tr/badge/doi/10.1016/j.chembiol.2015.06.010.svg", 
    "bucket": "https://aperta.ulakbim.gov.tr/api/files/433eeee7-fbff-46bc-8daf-d58cde73922a", 
    "doi": "https://doi.org/10.1016/j.chembiol.2015.06.010", 
    "html": "https://aperta.ulakbim.gov.tr/record/82211", 
    "latest": "https://aperta.ulakbim.gov.tr/api/records/82211", 
    "latest_html": "https://aperta.ulakbim.gov.tr/record/82211"
  }, 
  "metadata": {
    "access_right": "open", 
    "access_right_category": "success", 
    "communities": [
      {
        "id": "tubitak-destekli-proje-yayinlari"
      }
    ], 
    "creators": [
      {
        "affiliation": "Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA", 
        "name": "Gould, Neal S."
      }, 
      {
        "affiliation": "Childrens Hosp Philadelphia, Dept Biomed & Hlth Informat, Philadelphia, PA 19104 USA", 
        "name": "Evans, Perry"
      }, 
      {
        "affiliation": "Scripps Res Inst, Dept Chem, Jupiter, FL 33458 USA", 
        "name": "Martinez-Acedo, Pablo"
      }, 
      {
        "affiliation": "Akdeniz Univ, Dept Agr Biotechnol, TR-07985 Antalya, Turkey", 
        "name": "Marino, Stefano M."
      }, 
      {
        "affiliation": "Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA", 
        "name": "Gladyshev, Vadim N."
      }, 
      {
        "affiliation": "Scripps Res Inst, Dept Chem, Jupiter, FL 33458 USA", 
        "name": "Carroll, Kate S."
      }, 
      {
        "name": "Ischiropoulos, Harry"
      }
    ], 
    "description": "S-Acylation, S-glutathionylation, S-nitrosylation, and S-sulfenylation are prominent, chemically distinct modifications that regulate protein function, redox sensing, and trafficking. Although the biological significance of these modifications is increasingly appreciated, their integration in the proteome remains unknown. Novel mass spectrometry-based technologies identified 2,596 predominately unique sites in 1,319 mouse liver proteins under physiological conditions. Structural analysis localized the modifications in unique, evolutionary conserved protein segments, outside commonly annotated functional regions. Contrary to expectations, propensity for modification did not correlate with biophysical properties that regulate cysteine reactivity. However, the in vivo chemical reactivity is fine-tuned for specificity, demonstrated by the nominal complementation between the four modifications and quantitative proteomics which showed that a reduction in S-nitrosylation is not correlated with increased S-glutathionylation. A comprehensive survey uncovered clustering of modifications within biologically related protein networks. The data provide the first evidence for the occurrence of distinct, endogenous protein networks that undergo redox signaling through specific cysteine modifications.", 
    "doi": "10.1016/j.chembiol.2015.06.010", 
    "has_grant": false, 
    "journal": {
      "issue": "7", 
      "pages": "965-975", 
      "title": "CHEMISTRY & BIOLOGY", 
      "volume": "22"
    }, 
    "license": {
      "id": "cc-by"
    }, 
    "publication_date": "2015-01-01", 
    "relations": {
      "version": [
        {
          "count": 1, 
          "index": 0, 
          "is_last": true, 
          "last_child": {
            "pid_type": "recid", 
            "pid_value": "82211"
          }, 
          "parent": {
            "pid_type": "recid", 
            "pid_value": "82210"
          }
        }
      ]
    }, 
    "resource_type": {
      "subtype": "article", 
      "title": "Dergi makalesi", 
      "type": "publication"
    }, 
    "title": "Site-Specific Proteomic Mapping Identifies Selectively Modified Regulatory Cysteine Residues in Functionally Distinct Protein Networks"
  }, 
  "owners": [
    1
  ], 
  "revision": 1, 
  "stats": {
    "downloads": 10.0, 
    "unique_downloads": 10.0, 
    "unique_views": 43.0, 
    "version_downloads": 10.0, 
    "version_unique_downloads": 10.0, 
    "version_unique_views": 43.0, 
    "version_views": 44.0, 
    "version_volume": 2810.0, 
    "views": 44.0, 
    "volume": 2810.0
  }, 
  "updated": "2021-03-16T05:58:06.470071+00:00"
}