1 Ocak 2015 Dergi makalesi Açık Erişim

Ozlu, Nurhan; Qureshi, Mohammad H.; Toyoda, Yusuke; Renard, Bernhard Y.; Mollaoglu, Gurkan; Ozkan, Nazli E.; Bulbul, Selda; Poser, Ina; Timm, Wiebke; Hyman, Anthony A.; Mitchison, Timothy J.; Steen, Judith A.

MARC21 XML

<?xml version='1.0' encoding='UTF-8'?>
<record xmlns="http://www.loc.gov/MARC21/slim">
  <leader>00000nam##2200000uu#4500</leader>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Qureshi, Mohammad H.</subfield>
    <subfield code="u">Koc Univ, Dept Mol Biol &amp; Genet, Istanbul, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Toyoda, Yusuke</subfield>
    <subfield code="u">Max Planck Inst Mol Cell Biol &amp; Genet, Dresden, Germany</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Renard, Bernhard Y.</subfield>
    <subfield code="u">Robert Koch Inst, Res Grp Bioinformat NG 4, Berlin, Germany</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Mollaoglu, Gurkan</subfield>
    <subfield code="u">Koc Univ, Dept Mol Biol &amp; Genet, Istanbul, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Ozkan, Nazli E.</subfield>
    <subfield code="u">Koc Univ, Dept Mol Biol &amp; Genet, Istanbul, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Bulbul, Selda</subfield>
    <subfield code="u">Koc Univ, Dept Mol Biol &amp; Genet, Istanbul, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Poser, Ina</subfield>
    <subfield code="u">Max Planck Inst Mol Cell Biol &amp; Genet, Dresden, Germany</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Timm, Wiebke</subfield>
    <subfield code="u">Childrens Hosp Boston, Prote Ctr, Boston, MA USA</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Hyman, Anthony A.</subfield>
    <subfield code="u">Max Planck Inst Mol Cell Biol &amp; Genet, Dresden, Germany</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Mitchison, Timothy J.</subfield>
    <subfield code="u">Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA USA</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Steen, Judith A.</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="4">
    <subfield code="p">EMBO JOURNAL</subfield>
    <subfield code="v">34</subfield>
    <subfield code="n">2</subfield>
    <subfield code="c">251-265</subfield>
  </datafield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">user-tubitak-destekli-proje-yayinlari</subfield>
  </datafield>
  <datafield tag="540" ind1=" " ind2=" ">
    <subfield code="a">Creative Commons Attribution</subfield>
    <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield>
  </datafield>
  <datafield tag="024" ind1=" " ind2=" ">
    <subfield code="a">10.15252/embj.201385162</subfield>
    <subfield code="2">doi</subfield>
  </datafield>
  <datafield tag="245" ind1=" " ind2=" ">
    <subfield code="a">Quantitative comparison of a human cancer cell surface proteome between interphase and mitosis</subfield>
  </datafield>
  <datafield tag="100" ind1=" " ind2=" ">
    <subfield code="a">Ozlu, Nurhan</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="O">
    <subfield code="o">oai:zenodo.org:81317</subfield>
    <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield>
  </datafield>
  <datafield tag="650" ind1="1" ind2="7">
    <subfield code="2">opendefinition.org</subfield>
    <subfield code="a">cc-by</subfield>
  </datafield>
  <datafield tag="260" ind1=" " ind2=" ">
    <subfield code="c">2015-01-01</subfield>
  </datafield>
  <datafield tag="856" ind1="4" ind2=" ">
    <subfield code="u">https://aperta.ulakbim.gov.trrecord/81317/files/bib-58efd3c0-841f-4ed2-8251-bbb7ff3a954a.txt</subfield>
    <subfield code="z">md5:a57e2ed48d8a161d1370e56a45184fe3</subfield>
    <subfield code="s">276</subfield>
  </datafield>
  <datafield tag="542" ind1=" " ind2=" ">
    <subfield code="l">open</subfield>
  </datafield>
  <controlfield tag="005">20210316054557.0</controlfield>
  <controlfield tag="001">81317</controlfield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">publication</subfield>
    <subfield code="b">article</subfield>
  </datafield>
  <datafield tag="520" ind1=" " ind2=" ">
    <subfield code="a">The cell surface is the cellular compartment responsible for communication with the environment. The interior of mammalian cells undergoes dramatic reorganization when cells enter mitosis. These changes are triggered by activation of the CDK1 kinase and have been studied extensively. In contrast, very little is known of the cell surface changes during cell division. We undertook a quantitative proteomic comparison of cell surface-exposed proteins in human cancer cells that were tightly synchronized in mitosis or interphase. Six hundred and twenty-eight surface and surface-associated proteins in HeLa cells were identified; of these, 27 were significantly enriched at the cell surface in mitosis and 37 in interphase. Using imaging techniques, we confirmed the mitosis-selective cell surface localization of protocadherin PCDH7, a member of a family with anti-adhesive roles in embryos. We show that PCDH7 is required for development of full mitotic rounding pressure at the onset of mitosis. Our analysis provided basic information on how cell cycle progression affects the cell surface. It also provides potential pharmacodynamic biomarkers for anti-mitotic cancer chemotherapy.</subfield>
  </datafield>
</record>