1 Ocak 2015 Dergi makalesi Açık Erişim

Ogunniran, Kehinde Olurotimi; Mesubi, Micheal Adediran; Raju, K. V. S. N.; Narender, Tadigoppula

MARC21 XML

<?xml version='1.0' encoding='UTF-8'?>
<record xmlns="http://www.loc.gov/MARC21/slim">
  <leader>00000nam##2200000uu#4500</leader>
  <datafield tag="909" ind1="C" ind2="4">
    <subfield code="n">5</subfield>
    <subfield code="c">815-829</subfield>
    <subfield code="v">12</subfield>
    <subfield code="p">JOURNAL OF THE IRANIAN CHEMICAL SOCIETY</subfield>
  </datafield>
  <controlfield tag="005">20210316054134.0</controlfield>
  <datafield tag="909" ind1="C" ind2="O">
    <subfield code="o">oai:zenodo.org:80989</subfield>
    <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield>
  </datafield>
  <datafield tag="100" ind1=" " ind2=" ">
    <subfield code="u">Covenant Univ, Dept Chem, Coll Sci &amp; Technol, Ota, Ogun State, Nigeria</subfield>
    <subfield code="a">Ogunniran, Kehinde Olurotimi</subfield>
  </datafield>
  <datafield tag="520" ind1=" " ind2=" ">
    <subfield code="a">A template condensation of 2,6-dihydroxybenzaldehyde with nicotinic hydrazide at 20 A degrees C yielded a tridendate ligand with the formation of azomethine bond. The structure of the ligand, H3L2 was confirmed with the use of analytical and spectroscopic analysis such as CHN analysis, ESI mass spectrum, FTIR, UV-visible spectrum and NMR techniques. The use of 2D NMR further confirmed the structure of the ligand. Also, five ligand-metal complexes were synthesized using different techniques. The physico-chemical properties of the complexes were determined with the use of melting point determination, conductivity test, micro-analysis, metal content determination (AAS), magnetic susceptibility measurements, FTIR, UV-visible spectra, ESR, TG/DTG and p-Xray diffraction study. The structures of the metal complexes were elucidated based on the analytical and spectroscopic data obtained. However, the anti-tubercular activities of the compounds were evaluated against H37Rv strain of Mycobacterium tuberculosis, in vitro. The results obtained indicated that the metal complexes are more active than isoniazid with MIC = 0.91 A mu g/mL. V(II) complex was found to be the most active with MIC of 0.62 A mu g/mL while Cu(II) complex with MIC values of 0.85 A mu g/mL is the least potent among the metal complexes synthesized. However, the results of the cytotoxicity against vero cells indicated that the metal complexes are more toxic when compared to the standard drug.</subfield>
  </datafield>
  <datafield tag="542" ind1=" " ind2=" ">
    <subfield code="l">open</subfield>
  </datafield>
  <datafield tag="650" ind1="1" ind2="7">
    <subfield code="2">opendefinition.org</subfield>
    <subfield code="a">cc-by</subfield>
  </datafield>
  <datafield tag="540" ind1=" " ind2=" ">
    <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield>
    <subfield code="a">Creative Commons Attribution</subfield>
  </datafield>
  <controlfield tag="001">80989</controlfield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">publication</subfield>
    <subfield code="b">article</subfield>
  </datafield>
  <datafield tag="245" ind1=" " ind2=" ">
    <subfield code="a">Structural and in vitro anti-tubercular activity study of (E)-N'-(2,6-dihydroxybenzylidene)nicotinohydrazide and some transition metal complexes</subfield>
  </datafield>
  <datafield tag="260" ind1=" " ind2=" ">
    <subfield code="c">2015-01-01</subfield>
  </datafield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">user-tubitak-destekli-proje-yayinlari</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Kwara State Univ, Dept Chem, Molete, Kwara State, Nigeria</subfield>
    <subfield code="a">Mesubi, Micheal Adediran</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Indian Inst Technol, Div Polymer &amp; Funct Mat, Hyderabad, Andhra Pradesh, India</subfield>
    <subfield code="a">Raju, K. V. S. N.</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Cent Drug Res Inst, CSIR, Med &amp; Proc Chem Div, Lucknow 226001, Uttar Pradesh, India</subfield>
    <subfield code="a">Narender, Tadigoppula</subfield>
  </datafield>
  <datafield tag="856" ind1="4" ind2=" ">
    <subfield code="u">https://aperta.ulakbim.gov.trrecord/80989/files/bib-04678200-6179-4495-9cf5-98ec57b08b7e.txt</subfield>
    <subfield code="s">261</subfield>
    <subfield code="z">md5:69f5173603a814254e323a11b8219a4f</subfield>
  </datafield>
  <datafield tag="024" ind1=" " ind2=" ">
    <subfield code="a">10.1007/s13738-014-0544-1</subfield>
    <subfield code="2">doi</subfield>
  </datafield>
</record>