1 Ocak 2015 Dergi makalesi Açık Erişim

Hayta, Burcu Balci; Ozdamar, Sevim Erdem; Dincer, Pervin

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/78913</identifier>
  <creators>
    <creator>
      <creatorName>Hayta, Burcu Balci</creatorName>
      <givenName>Burcu Balci</givenName>
      <familyName>Hayta</familyName>
      <affiliation>Hacettepe Univ, Dept Med Biol, Fac Med, TR-06100 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozdamar, Sevim Erdem</creatorName>
      <givenName>Sevim Erdem</givenName>
      <familyName>Ozdamar</familyName>
      <affiliation>Hacettepe Univ, Dept Neurol &amp; Neuromuscular Dis Res Lab, Fac Med, TR-06100 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Dincer, Pervin</creatorName>
      <givenName>Pervin</givenName>
      <familyName>Dincer</familyName>
      <affiliation>Hacettepe Univ, Dept Med Biol, Fac Med, TR-06100 Ankara, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Proinflammatory Effect Of Abetapp Induced St6Gal1 Secretion From C2C12 Myogenic Cell Line</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2015</publicationYear>
  <dates>
    <date dateType="Issued">2015-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/78913</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.5505/tjb.2015.46547</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Objective: ST6 beta galactosamide alpha-2,6-sialyltranferase 1 (ST6GAL1), the major alpha 2,6-sialyltransferase responsible for the broad synthesis of glycoproteins and glycolipids, is another physiological substrate of Beta site APP-cleaving enzyme 1 (BACE1) other than amyloid-beta precursor protein (AbetaPP). We have previously shown that AbetaPP overexpression in C2C12 mouse myoblast cell line increased the expression and secretion of ST6GAL1 enzyme under in vitro conditions. Since the secretion of ST6GAL1 is known to be enhanced during inflammation, we investigated whether AbetaPP induced ST6GAL1 secretion from C2C12 cells affected proinflammatory cytokine production by J774 mouse macrophage cell line.</description>
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