1 Ocak 2015 Dergi makalesi Açık Erişim

Eryilmaz, Ufuk; Demirci, Buket; Aksun, Saliha; Boyacioglu, Murat; Akgullu, Cagdas; Ilgenli, Tevfik Fikret; Yalinkilinc, Hande Sultan; Bilgen, Mehmet

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/77057</identifier>
  <creators>
    <creator>
      <creatorName>Eryilmaz, Ufuk</creatorName>
      <givenName>Ufuk</givenName>
      <familyName>Eryilmaz</familyName>
      <affiliation>Adnan Menderes Univ, Fac Med, Dept Cardiol, Aydin, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Demirci, Buket</creatorName>
      <givenName>Buket</givenName>
      <familyName>Demirci</familyName>
      <affiliation>Adnan Menderes Univ, Fac Med, Dept Med Pharmacol, Aydin, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Aksun, Saliha</creatorName>
      <givenName>Saliha</givenName>
      <familyName>Aksun</familyName>
      <affiliation>Katip Celebi Univ, Fac Med, Dept Med Biochem, Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Boyacioglu, Murat</creatorName>
      <givenName>Murat</givenName>
      <familyName>Boyacioglu</familyName>
      <affiliation>Adnan Menderes Univ, Fac Vet Med, Dept Pharmacol &amp; Toxicol, Aydin, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Akgullu, Cagdas</creatorName>
      <givenName>Cagdas</givenName>
      <familyName>Akgullu</familyName>
      <affiliation>Adnan Menderes Univ, Fac Med, Dept Cardiol, Aydin, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ilgenli, Tevfik Fikret</creatorName>
      <givenName>Tevfik Fikret</givenName>
      <familyName>Ilgenli</familyName>
      <affiliation>Konya Selcuklu Private Hosp, Dept Cardiol, Konya, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Yalinkilinc, Hande Sultan</creatorName>
      <givenName>Hande Sultan</givenName>
      <familyName>Yalinkilinc</familyName>
      <affiliation>Adnan Menderes Univ, Fac Vet Med, Dept Pharmacol &amp; Toxicol, Aydin, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Bilgen, Mehmet</creatorName>
      <givenName>Mehmet</givenName>
      <familyName>Bilgen</familyName>
      <affiliation>Adnan Menderes Univ, Fac Med, Dept Biophys, Aydin, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>S100A1 As A Potential Diagnostic Biomarker For Assessing Cardiotoxicity And Implications For The Chemotherapy Of Certain Cancers</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2015</publicationYear>
  <dates>
    <date dateType="Issued">2015-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/77057</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1371/journal.pone.0145418</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">This study examined the value of blood marker S100A1 in detecting cardiotoxicity induced by chemotherapy agents; trastuzumab and lapatinib, in normal rat heart. The rats were divided into three groups: control (n = 8, no treatment), T (n = 8, one time ip treatment with 10mg/kg trastuzumab) and L (n = 8, oral treatment with 100 mg/kg/day lapatinib for 7 days). The activities of oxidative stress parameters Malondialdehyde (MDA), Superoxide dismutase (SOD), Catalase (CAT) and Glutathione (GSH) were measured from the extracted cardiac tissues. The levels of troponinI and S100A1 expressions were measured from blood samples. All biomarkers responded to the treatments as they exhibited alterations from their normative values, validating the chemically induced cardiotoxicity. S100A1 expression attenuated significantly (75%), which made the sensitive detection of cardiotoxicity feasible. Assessment of cardiotoxicity with S100A1 may be a valuable alternative in clinical oncology of cancers in some organs such as breast and prostate, as they do not overexpress it to compete against.</description>
  </descriptions>
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