1 Ocak 2015 Dergi makalesi Açık Erişim

Loo, Yihua; Goktas, Melis; Tekinay, Ayse B.; Guler, Mustafa O.; Hauser, Charlotte A. E.; Mitraki, Anna

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/76641</identifier>
  <creators>
    <creator>
      <creatorName>Loo, Yihua</creatorName>
      <givenName>Yihua</givenName>
      <familyName>Loo</familyName>
      <affiliation>ASTAR, Inst Bioengn &amp; Nanotechnol, The Nanos 138669, Singapore</affiliation>
    </creator>
    <creator>
      <creatorName>Goktas, Melis</creatorName>
      <givenName>Melis</givenName>
      <familyName>Goktas</familyName>
      <affiliation>Bilkent Univ, Natl Nanotechnol Res Ctr UNAM, Inst Mat Sci &amp; Nanotechnol, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Tekinay, Ayse B.</creatorName>
      <givenName>Ayse B.</givenName>
      <familyName>Tekinay</familyName>
      <affiliation>Bilkent Univ, Natl Nanotechnol Res Ctr UNAM, Inst Mat Sci &amp; Nanotechnol, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Guler, Mustafa O.</creatorName>
      <givenName>Mustafa O.</givenName>
      <familyName>Guler</familyName>
      <affiliation>Bilkent Univ, Natl Nanotechnol Res Ctr UNAM, Inst Mat Sci &amp; Nanotechnol, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Hauser, Charlotte A. E.</creatorName>
      <givenName>Charlotte A. E.</givenName>
      <familyName>Hauser</familyName>
      <affiliation>ASTAR, Inst Bioengn &amp; Nanotechnol, The Nanos 138669, Singapore</affiliation>
    </creator>
    <creator>
      <creatorName>Mitraki, Anna</creatorName>
      <givenName>Anna</givenName>
      <familyName>Mitraki</familyName>
    </creator>
  </creators>
  <titles>
    <title>Self-Assembled Proteins And Peptides As Scaffolds For Tissue Regeneration</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2015</publicationYear>
  <dates>
    <date dateType="Issued">2015-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/76641</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1002/adhm.201500402</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Self-assembling proteins and peptides are increasingly gaining interest for potential use as scaffolds in tissue engineering applications. They self-organize from basic building blocks under mild conditions into supramolecular structures, mimicking the native extracellular matrix. Their properties can be easily tuned through changes at the sequence level. Moreover, they can be produced in sufficient quantities with chemical synthesis or recombinant technologies to allow them to address homogeneity and standardization issues required for applications. Here. recent advances in self-assembling proteins, peptides, and peptide amphiphiles that form scaffolds suitable for tissue engineering are reviewed. The focus is on a variety of motifs, ranging from minimalistic dipeptides, simplistic ultrashort aliphatic peptides, and peptide amphiphiles to large "recombinamer" proteins. Special emphasis is placed on the rational design of self-assembling motifs and biofunctionalization strategies to influence cell behavior and modulate scaffold stability. Perspectives for combination of these "bottom-up" designer strategies with traditional "top-down" biofabrication techniques for new generations of tissue engineering scaffolds are highlighted.</description>
  </descriptions>
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