1 Ocak 2019 Dergi makalesi Açık Erişim

Rencber, Seda; Cheaburu-Yilmaz, Catalina Natalia; Kose, Fadime Aydin; Karavana, Sinem Yaprak; Yilmaz, Onur

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{
  "@context": "https://schema.org/", 
  "@id": 76231, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Ege Univ, Dept Pharmaceut Technol, Fac Pharm, TR-35100 Izmir, Turkey", 
      "name": "Rencber, Seda"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Petru Poni Inst Macromol Chem, Iasi 700487, Romania", 
      "name": "Cheaburu-Yilmaz, Catalina Natalia"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ege Univ, Dept Biochem, Fac Pharm, TR-35100 Izmir, Turkey", 
      "name": "Kose, Fadime Aydin"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ege Univ, Dept Pharmaceut Technol, Fac Pharm, TR-35100 Izmir, Turkey", 
      "name": "Karavana, Sinem Yaprak"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ege Univ, Leather Engn Dept, Fac Engn, TR-35100 Izmir, Turkey", 
      "name": "Yilmaz, Onur"
    }
  ], 
  "datePublished": "2019-01-01", 
  "description": "Interpolymeric complexes (IPCs) have the advantage of combined properties of their constituent polymers. They are easy to prepare under mild conditions and do not require high processing costs. The interpolymeric complexes of alginate, chitosan and Nystatin, as antifungal drug systems, represent an alternative for mucosal illness treatment. The composition of the two polymers is a key parameter in obtaining the desired properties for pharmaceutical formulations. IPCs of sodium alginate (SA) and chitosan (CS) were prepared via solution mixing method with various compositions, followed by coacervation in 2-propanol. The outcome obtained from rheological measurements was that the complex SA/CS 60/40 (v/v %) fulfilled the requirements of a semi-solid formulation, e.g. pseudoplasticity. Nystatin showed very good compatibility with the polymeric system. The drug loaded gels showed better rheological, textural and mechanical properties (e.g. pseudoelasticity, spreadability, surface adhesion etc.). The final gel formulations showed no cytotoxic effects in the cell culture assay.", 
  "headline": "PREPARATION AND CHARACTERIZATION OF ALGINATE AND CHITOSAN IPC BASED GEL FORMULATION FOR MUCOSAL APPLICATION", 
  "identifier": 76231, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "PREPARATION AND CHARACTERIZATION OF ALGINATE AND CHITOSAN IPC BASED GEL FORMULATION FOR MUCOSAL APPLICATION", 
  "url": "https://aperta.ulakbim.gov.tr/record/76231"
}