1 Ocak 2019 Dergi makalesi Açık Erişim

Kenar, Halime; Ozdogan, Candan Yilmaz; Dumlu, Cansu; Doger, Emek; Kose, Gamze Torun; Hasirci, Vasif

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/76049</identifier>
  <creators>
    <creator>
      <creatorName>Kenar, Halime</creatorName>
      <givenName>Halime</givenName>
      <familyName>Kenar</familyName>
    </creator>
    <creator>
      <creatorName>Ozdogan, Candan Yilmaz</creatorName>
      <givenName>Candan Yilmaz</givenName>
      <familyName>Ozdogan</familyName>
    </creator>
    <creator>
      <creatorName>Dumlu, Cansu</creatorName>
      <givenName>Cansu</givenName>
      <familyName>Dumlu</familyName>
      <affiliation>Kocaeli Univ, Polymer Sci &amp; Technol Dept, Grad Sch Nat &amp; Appl Sci, Izmit, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Doger, Emek</creatorName>
      <givenName>Emek</givenName>
      <familyName>Doger</familyName>
      <affiliation>Kocaeli Univ, Dept Gynecol &amp; Obstet, Izmit, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kose, Gamze Torun</creatorName>
      <givenName>Gamze Torun</givenName>
      <familyName>Kose</familyName>
    </creator>
    <creator>
      <creatorName>Hasirci, Vasif</creatorName>
      <givenName>Vasif</givenName>
      <familyName>Hasirci</familyName>
    </creator>
  </creators>
  <titles>
    <title>Microfibrous Scaffolds From Poly(L-Lactide-Co-Epsilon-Caprolactone) Blended With Xeno-Free Collagen/Hyaluronic Acid For Improvement Of Vascularization In Tissue Engineering Applications</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2019</publicationYear>
  <dates>
    <date dateType="Issued">2019-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/76049</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.msec.2018.12.011</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Success of 3D tissue substitutes in clinical applications depends on the presence of vascular networks in their structure. Accordingly, research in tissue engineering is focused on the stimulation of angiogenesis or generation of a vascular network in the scaffolds prior to implantation. A novel, xeno-free, collagen/hyaluronic acid-based poly(L-lactide-co-epsilon-caprolactone) (PLC/COL/HA) (20/9.5/0.5 w/w/w) microfibrous scaffold was produced by electrospinning. Collagen types I and III, and hyaluronic acid were isolated from human umbilical cords and blended with the GMP grade PLC. When compared with PLC scaffolds the PLC/COL/HA had higher water uptake capacity (103% vs 66%) which may have contributed to the decrease in its Young's Modulus (from 1.31 to 0.89 MPa). The PLC/COL/HA better supported adipose tissue-derived mesenchymal stem cell (AT MSC) adhesion; within 24 h the cell number on the PLC/COL/HA scaffolds was 3 fold higher. Co-culture of human umbilical vein endothelial cells and AT MSCs induced capillary formation on both scaffold types, but the PLC/COL/HA led to formation of interconnected vessels whose total length was 1.6 fold of the total vessel length on PLC. Clinical use of this scaffold would eliminate the immune response triggered by xenogeneic collagen and transmission of animal-borne diseases while promoting a better vascular network formation.</description>
  </descriptions>
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